Dow futures up over 1000 pts
Nice timing!
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Dow futures up over 1000 pts
Nice timing!
by Anonymous | reply 288 | December 17, 2020 10:37 PM |
đ As if Trump wasnât depressed enough.
by Anonymous | reply 1 | November 9, 2020 12:01 PM |
Let other people be the guinea pigs.
by Anonymous | reply 2 | November 9, 2020 12:01 PM |
Trump will celebrate and take the W for the vaccine.
by Anonymous | reply 3 | November 9, 2020 12:07 PM |
Thanks for waiting a week, Pfizer! đ
by Anonymous | reply 4 | November 9, 2020 12:08 PM |
[QUOTE] Trump will celebrate and take the W for the vaccine.
President Biden and his experts will be the one leading the efforts to distribute this vaccine.
by Anonymous | reply 5 | November 9, 2020 12:12 PM |
damm right R5
Europe markets up 4%, Dow futures now up 1300 pts
by Anonymous | reply 6 | November 9, 2020 12:14 PM |
THEY WAITED A WEEK SO LEADER WOULD LOSE!!!!!!!
by Anonymous | reply 7 | November 9, 2020 12:18 PM |
This should be the top story in the news.
by Anonymous | reply 8 | November 9, 2020 12:18 PM |
Finally some good news! There's light at the end of the tunnel.
by Anonymous | reply 9 | November 9, 2020 12:20 PM |
How is this good news? What about the 10% of us?
by Anonymous | reply 10 | November 9, 2020 12:26 PM |
I told my friends the other day that there would likely be a vaccine before summer. I might have been right.
by Anonymous | reply 11 | November 9, 2020 12:26 PM |
Debbie Downer @ R10
by Anonymous | reply 12 | November 9, 2020 12:28 PM |
They waited a week because Dump and Jared would have fucked the population over on distribution while figuring out how they could first line their pockets.
by Anonymous | reply 13 | November 9, 2020 12:30 PM |
Do the 10% who arenât âeffectiveâ die? If so, no thanks, itâs worse than my chances with Rona.
by Anonymous | reply 14 | November 9, 2020 12:33 PM |
What makes you think they waited a week? Maybe they just discovered it yesterday.
by Anonymous | reply 15 | November 9, 2020 12:34 PM |
Science r10
by Anonymous | reply 16 | November 9, 2020 12:34 PM |
Thanks Pfizer for not announcing last Monday!
by Anonymous | reply 17 | November 9, 2020 12:37 PM |
Really, R10? Are you that dense? Itâs 90% effective against getting it, not protecting you from dying if you do get it. And getting even a mild case can pose all kinds of long term effects. But you do you.
by Anonymous | reply 18 | November 9, 2020 12:41 PM |
I meant R14.
by Anonymous | reply 19 | November 9, 2020 12:41 PM |
[quote] Do the 10% who arenât âeffectiveâ die?
10% of the participants got the virus, but we know the fatality rate is now very low, so most will be okay.
by Anonymous | reply 20 | November 9, 2020 12:42 PM |
I have R14 blocked, most likely because she's a cunt and a troll.
by Anonymous | reply 21 | November 9, 2020 12:44 PM |
Check Ok?
by Anonymous | reply 22 | November 9, 2020 12:45 PM |
r18 not exactly. If it's effective in 90% of the population it'll pretty much create herd immunity. r10 is dense though.
by Anonymous | reply 23 | November 9, 2020 12:49 PM |
[quote] 10% of the participants got the virus, but we know the fatality rate is now very low, so most will be okay.
Why would you want to be the 10% who got the virus? Even if you wonât die. Pfizer really think they did something, didnât they. No thanks, Iâm good. Iâll wait til they come correct with a đŻ% effective vaccine and they better come correct. Until then, fuck Pfizer.
by Anonymous | reply 24 | November 9, 2020 12:54 PM |
^LOL
by Anonymous | reply 25 | November 9, 2020 12:57 PM |
It's about as effective as the measles vaccine. Which is regarded as highly effective.
by Anonymous | reply 26 | November 9, 2020 12:57 PM |
[quote]10% of the participants got the virus
As a result of taking the vaccine?
by Anonymous | reply 27 | November 9, 2020 12:59 PM |
Isnât the flu vaccine only 50% effective? In comparison, this sounds almost too good to be true.
by Anonymous | reply 28 | November 9, 2020 1:00 PM |
Congratulations to the German biotech company BioNTech that developed this vaccine. Pfizer were smart to choose to partner with them.
by Anonymous | reply 29 | November 9, 2020 1:00 PM |
I'm sitting at home with a bf who I'm almost certain has COVID, we're hopefully going to get a test today, it would just fucking figure that they'd have a vaccine out three weeks after he caught it.
by Anonymous | reply 30 | November 9, 2020 1:00 PM |
But the Oxford camp has warned that the effectiveness of the vaccine will decrease markedly in obese people. Fat whores bemoan!!!
by Anonymous | reply 31 | November 9, 2020 1:01 PM |
R30, the vaccine is not going to be out for many weeks, many months more likely.
by Anonymous | reply 32 | November 9, 2020 1:01 PM |
[QUOTE] But the Oxford camp has warned that the effectiveness of the vaccine will decrease markedly in obese people.
The effectiveness of everything decreases markedly in obese people.
by Anonymous | reply 33 | November 9, 2020 1:03 PM |
I guess the Republicans were right when they said all of this would end after they got Trump out of office. They're going to say this proves COVID was all a big plot to take him down and refuse to take it.
by Anonymous | reply 34 | November 9, 2020 1:05 PM |
Hey everyone, let the morons who say they wonât be vaccinated alone. Weâll be vaccinated!i know I know, they are a risk to the 10 percent for whom the vaccination will be effective, but theyâre morons so who cares? Darwinism!
Vaccines that are 90 percent effective are considered very effective btw.
by Anonymous | reply 35 | November 9, 2020 1:06 PM |
90% effective, right because they have done such extensive testing.
Neurological symptoms are a side effect of the Oxford vaccine.
Across Europe the virus has mutated because of the mink farms and has been transferred to peoples. Well at least the farms will be closed within the next few months. The current vaccines they are working on donât work on mutations.
Iâm kind of sceptic about it all. Is it in any proven way effective or mainly money and business.
by Anonymous | reply 36 | November 9, 2020 1:06 PM |
people
by Anonymous | reply 37 | November 9, 2020 1:07 PM |
[quote] The effectiveness of everything decreases markedly in obese people.
Especially logic
by Anonymous | reply 38 | November 9, 2020 1:07 PM |
[quote]Isnât the flu vaccine only 50% effective? In comparison, this sounds almost too good to be true.
Keep in mind that this news was delivered in a press release, not a peer-reviewed medical journal, so the 90% figure might turn out to be a bit rosy. But wouldn't it be great?
[quote]President Biden and his experts will be the one leading the efforts to distribute this vaccine.
60 Minutes did a story last night on the army's efforts to gear up for distribution of the vaccine. It seems like they're on a good track.
by Anonymous | reply 39 | November 9, 2020 1:08 PM |
I would not take a vaccine developed under the Trump administration.
by Anonymous | reply 40 | November 9, 2020 1:09 PM |
If they are talking about infection rate then 90% effective means 90% fewer people in the treatment group got infected than the placebo group. If they are talking about disease severity then the disease severity was lessened by 90% in the treatment group. I donât know which end point they are announcing, but either way great news.
by Anonymous | reply 41 | November 9, 2020 1:10 PM |
Is it 2-dose vaccine which has to be stored in a very cool place? Then human errors will fuck it all up again.
by Anonymous | reply 42 | November 9, 2020 1:12 PM |
Itâs infections - extraordinarily wonderful news.
FWIW R40 Pfizer was the only company in phase 3 SARS-CoV-2 vaccine development who didnât take BARDA money for the studies. They will be getting BARDA money for distribution however.
by Anonymous | reply 43 | November 9, 2020 1:14 PM |
"The analysis evaluated 94 confirmed Covid-19 infections among the trialâs 43,538 participants. Pfizer and the U.S. pharmaceutical giantâs German biotech partner said the case split between vaccinated individuals and those who received a placebo indicated a vaccine efficacy rate of above 90% at seven days after the second dose.
It means that protection from Covid-19 is achieved 28 days after the initial vaccination, which consists of a two-dose schedule.
The final vaccine efficacy percentage may vary, however, as safety and additional data continue to be collected."
by Anonymous | reply 44 | November 9, 2020 1:15 PM |
-80 freezers R42
by Anonymous | reply 45 | November 9, 2020 1:15 PM |
R36? Please tell me that English isn't your first language.
by Anonymous | reply 46 | November 9, 2020 1:16 PM |
Yes, weâd like to know the safety profile, including adverse events and permanent side effects.
by Anonymous | reply 47 | November 9, 2020 1:16 PM |
[quote] Do the 10% who arenât âeffectiveâ die? If so, no thanks, itâs worse than my chances with Rona.
Yes. It means 1 out of every 10 who are given it will die of rapid onset old age. Hereâs footage of the arrogant CEO of Pfizer taking the first dose:
by Anonymous | reply 48 | November 9, 2020 1:16 PM |
[QUOTE] The final vaccine efficacy percentage may vary
In other words that 90% figure is probably bullshit.
by Anonymous | reply 49 | November 9, 2020 1:17 PM |
We have only Pfizer's hype--no other verification or confirmation.
They're pimping their stock.
by Anonymous | reply 50 | November 9, 2020 1:18 PM |
Itâs better than What we have now which is absolutely nothing.
Oh and I have 52 Pfizer shares so yeah for that.
by Anonymous | reply 51 | November 9, 2020 1:18 PM |
[QUOTE] Itâs better than What we have now which is absolutely nothing.
R51 probably owns stock in Pfizer. Admit it.
by Anonymous | reply 52 | November 9, 2020 1:19 PM |
R40, this vaccine has been developed under Chancellor Merkel (PhD in quantum chemistry) in Germany by BioNTech of Mainz. Pfizer is helping with the manufacturing and distribution.
by Anonymous | reply 53 | November 9, 2020 1:20 PM |
For the skeptical in New York, there is an extra layer of review.
by Anonymous | reply 54 | November 9, 2020 1:23 PM |
[quote]Do the 10% who arenât âeffectiveâ die? If so, no thanks, itâs worse than my chances with Rona.
Yes, Rose. The vaccine kills 10% of the people who take it. That's exactly how it works. :eyeroll:
by Anonymous | reply 55 | November 9, 2020 1:24 PM |
Didn't the Russian team also brag that their vaccine was 90% effective as well? Where is it now though? Putin must have tried it and got dementia as an adverse effect.
by Anonymous | reply 56 | November 9, 2020 1:25 PM |
Biden has named three physicians to head up the coronavirus task force. I have far more faith in them than I do in people like Mike Pence and Scott Atlas.
Imagine, real medical experts leading a pandemic response team. To steal a phrase from Ronald Reagan (yeeech), it really is 'Morning in America'
by Anonymous | reply 57 | November 9, 2020 1:27 PM |
Needs to be stored in -80 degrees? Does it take 6 months to thaw it out? Or do they shoot into your arm REALLY cold?
by Anonymous | reply 58 | November 9, 2020 1:27 PM |
[quote]I would not take a vaccine developed under the Trump administration.
Good lord. It wasn't developed "under the Trump administration." He doesn't control everything on the planet, as much as he might wish he did.
by Anonymous | reply 59 | November 9, 2020 1:29 PM |
When they get a vaccine that's 99% or above effective, I'll get a puncture.
by Anonymous | reply 60 | November 9, 2020 1:30 PM |
R60, no vaccine is "99% or above effective." That's incredibly stupid of you.
by Anonymous | reply 61 | November 9, 2020 1:33 PM |
My epidemiologist friends say this is interesting, but will need to see the results themselves, and that could take months.
by Anonymous | reply 62 | November 9, 2020 1:33 PM |
[QUOTE] When they get a vaccine that's 99% or above effective, I'll get a puncture.
Maybe if youâd lower your standards, youâd get punctured a lot more often.
by Anonymous | reply 63 | November 9, 2020 1:34 PM |
While this is great news, I'm dreading Trump and his cult thinking he gets credit for this.
by Anonymous | reply 64 | November 9, 2020 1:34 PM |
[quote]When they get a vaccine that's 99% or above effective, I'll get a puncture
you're being silly, no vaccine is that effective, even for the chicken pox. at this speed if they get an vaccine that is around 80 percent efficacy then it would change the world
by Anonymous | reply 65 | November 9, 2020 1:34 PM |
It's already started, R64.
[quote]STOCK MARKET UP BIG, VACCINE COMING SOON. REPORT 90% EFFECTIVE. SUCH GREAT NEWS!
by Anonymous | reply 67 | November 9, 2020 1:39 PM |
[quote]I would not take a vaccine developed under the Trump administration.
Pfizer released a statement saying that they were not part of Trump's Operation Warp Speed.
by Anonymous | reply 68 | November 9, 2020 1:40 PM |
People are understandably clueless here. 90% effectice is incredible, everybody is shocked by these numbers.
Two things though
1) This daya hasn't gone through a thorough peer review yet
2) They aren't finished yet so it will likely drop someone.
Regardless anywhere close to 90% achieves herd immunity if this holds.
It would be likely be ready to emergency use by end of the year but not ready to be distributed broadly until well into 2021.
by Anonymous | reply 69 | November 9, 2020 1:41 PM |
Biden's language is purposeful r66, the scientist leading this effort at Pfizer is a woman.
by Anonymous | reply 70 | November 9, 2020 1:42 PM |
Merkel Vaccine! Rebrand now to cut Dumpâs propaganda off at the knees.
by Anonymous | reply 71 | November 9, 2020 1:43 PM |
very good
by Anonymous | reply 72 | November 9, 2020 1:44 PM |
[QUOTE] Biden statement:
It will be nice to have the adults in charge again.
by Anonymous | reply 73 | November 9, 2020 1:46 PM |
[quote] Regardless anywhere close to 90% achieves herd immunity if this holds.
The herd immunity people said we would never achieve.
by Anonymous | reply 74 | November 9, 2020 2:01 PM |
R67 I'm sure you and I aren't the only two who will celebrate the day when Dear Leader's tweets remain unreported in the media
by Anonymous | reply 75 | November 9, 2020 2:02 PM |
r74 Experts said that herd immunity could not be achieved through infections without a massive death toll. They were not talking about herd immunity achieved through vaccination. If enough anti-vaxxers refuse vaccination, it could still be difficult to achieve herd immunity.
by Anonymous | reply 76 | November 9, 2020 2:13 PM |
It still hasn't had the usual amount of length of testing? Emergency release cuts that down.
by Anonymous | reply 77 | November 9, 2020 2:15 PM |
R74, in the real world herd immunity can be achieved with mass vaccination. It can practically not be achieved by letting the virus spread as much as possible through the population in the hope that most people get it and then they will be immune, thus achieving "natural herd immunity" that way - which is what the no lockdown, no restrictions people were trying to claim.
by Anonymous | reply 78 | November 9, 2020 2:26 PM |
r74 was blocked
but if the numbers that roughly one quarter of NYers were positive for covid at one time, and the enormous death toll occurring there, for the whole of the country to gain herd immunity would require millions of deaths all across the country, a hecatomb
by Anonymous | reply 79 | November 9, 2020 2:32 PM |
I would prefer all these scientists work on building a time machine that can take us back to before Reagan was elected.
by Anonymous | reply 80 | November 9, 2020 2:33 PM |
Why did FB dump at the open?
by Anonymous | reply 81 | November 9, 2020 2:33 PM |
If Biden and Harris get the vaccine, I'm going to run to get it. I trust them.
by Anonymous | reply 82 | November 9, 2020 2:34 PM |
[quote]I would prefer all these scientists work on building a time machine that can take us back to before Reagan was elected.
You'd still have to live through the 80s again
by Anonymous | reply 83 | November 9, 2020 2:38 PM |
R83, I was a little kid in the 80s. All I really remember is Mr. Rogers and my dad throwing plates at the walls.
by Anonymous | reply 84 | November 9, 2020 2:42 PM |
[quote] The effectiveness of everything decreases markedly in obese people.
Not true. The effectiveness of donuts doesnât.
by Anonymous | reply 85 | November 9, 2020 2:47 PM |
Please tell me youâre being sarcastic or are you that dumb?
The man said:
[quote] Itâs better than What we have now which is absolutely nothing. [bold]Oh and I have 52 Pfizer shares so yeah for that.[/bold]
And you really
[quote][R51] probably owns stock in Pfizer. Admit it.
Really?
by Anonymous | reply 86 | November 9, 2020 2:49 PM |
*and you reply
by Anonymous | reply 87 | November 9, 2020 2:49 PM |
r81 Trump's Deplorables are moving to "uncensored" Parler. Trump's failure to concede defeat is probably causing even more Deplorables to leave Facebook.
by Anonymous | reply 88 | November 9, 2020 2:50 PM |
Correct r68. Pfizer was not part of Operation Warp Speed so the Trump administration cannot take any credit for this one.
Of course, they will anyway.
by Anonymous | reply 89 | November 9, 2020 2:53 PM |
Did G/R/Umpy come back and I wasnât notified?
by Anonymous | reply 90 | November 9, 2020 2:56 PM |
R90, sadly, no. Umpy was, if nothing else, amusing.
by Anonymous | reply 91 | November 9, 2020 2:57 PM |
Even more importantly r89, the vaccine was mostly developed in Germany by BioNTech, not by Pfizer in the US. In fact, it was developed by Muslim immigrants to Germany.
by Anonymous | reply 92 | November 9, 2020 2:57 PM |
R92, it was invented by everything they hate! Science! Women! Muslims! Foreigners!
by Anonymous | reply 93 | November 9, 2020 2:59 PM |
What arethe negative effects? Besides your dick falling off?
by Anonymous | reply 94 | November 9, 2020 3:13 PM |
R24 No vaccine is 100% effective, most of our vaccines are around 80-95% effective. Also even if not fully preventative, the full extent of symptoms are lessened. There is a subset of people, very small minority who are vaccine non-responders, meaning they donât develop antibodies as proof of immunity. But thatâs a small percentage of the population, data varies but most state that itâs around 0.5-2-3%. Also just if youâre a non-responder to one vaccine/ vaccine series, it doesnât mean it applies to all vaccines.
I found out I was a non-responder to the MMR vaccine series when I got my first job as RN, and I was tested for MMR immunity as part of employment health screening. Tested negative for measles immunity so I received another series. Still negative so they gave a another yet one more series. Negative again. They had to consult with CDC and was told that I shouldnât receive any more MMR series (after 5 series in my lifetime), and I was counseled to be vigilant about not exposing myself to patients with suspected or diagnosed measles. I rely on herd immunity to not get measles, adults who get measles are likely to have a more serious course so not something I take lightly.
Now in my capacity as DNP I often counsel patients on the importance of vaccination and herd immunity. What is disappointing about the misinformation and mistrust of vaccine science is that many people have already decided against taking any COVID-19 vaccines out of fear. Fear thatâs been stoked by politics.
by Anonymous | reply 95 | November 9, 2020 3:15 PM |
There absolutely are Pfizer run trials in the US in addition to Germany.
No to OWS on study funding, yes to OWS on distribution funding.
by Anonymous | reply 96 | November 9, 2020 3:25 PM |
We'll see how it goes. I don't have any confidence in this vaccine just off of an announcement by Pfizer.
by Anonymous | reply 97 | November 9, 2020 3:48 PM |
I'm not taking their fucking word for it.
by Anonymous | reply 98 | November 9, 2020 3:50 PM |
[quote] it was invented by everything they hate! Science! Women! Muslims! Foreigners!
Yeah, well those towel-heads invented the zero too! And then what did they have -- nothing!
by Anonymous | reply 99 | November 9, 2020 3:53 PM |
Zero is a commie Muslim conspiracy!
by Anonymous | reply 100 | November 9, 2020 4:00 PM |
Doesn't it take 1-2 years for FDA approval?
What are the long-term effects?
I think the rapture over this news should be muted.
by Anonymous | reply 101 | November 9, 2020 4:09 PM |
You won't have to take their word on it -- they'll undoubtably be publishing their results.
by Anonymous | reply 102 | November 9, 2020 4:09 PM |
Numbersâ in-cluding âzeroâ is a librul construck! I aint never trussed them dang thingâs! Look what numbersâ done did to my pressedant!!
by Anonymous | reply 103 | November 9, 2020 4:12 PM |
R101 not with Kessel on Bidenâs CV19 team. Kessel is an evil bastard who should be in prison.
by Anonymous | reply 104 | November 9, 2020 4:12 PM |
If you think âbout it, zero doesnât even exist. How can there be nuthinâ of something? If there wasnât one of âem, you wouldnât even have a name for it. Them Satanists been playing the long game since they done invented so-called math.
by Anonymous | reply 105 | November 9, 2020 4:14 PM |
[quote] the vaccine was mostly developed in Germany by BioNTech, not by Pfizer in the US. In fact, it was developed by Muslim immigrants to Germany.
Knowing how Germans will always be, itâs likely it was tested on Muslim immigrants in the Germanâs âexperimentsâ.
by Anonymous | reply 106 | November 9, 2020 4:17 PM |
I've already had a 'vaccine'. It's called "Haditimmunenow"
by Anonymous | reply 107 | November 9, 2020 4:19 PM |
BioNTech hopes COVID-19 vaccine will immunize for at least a year
By Ludwig Burger, Patricia Weiss
FRANKFURT (Reuters) - BioNTech's BNTX.O co-founder and chief executive said he was optimistic that the protective effect of its experimental COVID-19 vaccine, co-developed with Pfizer PFE.N, would last for at least a year.
The two companies earlier on Monday became the first drugmakers to release successful trial data, saying their vaccine was shown to be more than 90% effective, a major victory in the fight against the pandemic.
âWe should be more optimistic that the immunisation effect can last for at least a year,â CEO Ugur Sahin told Reuters.
While it was not yet known how long the protection would last, he said research on recovered patients had shown that those with high antibodies levels to begin with have not experienced a sharp drop in those levels, and the same would likely go for vaccinated people.
Highlighting the logistical challenge of distributing the vaccine, which belongs to a class known as messenger RNA, the arrangement for the first three months would be that the genetic compound would have to be shipped and centrally stored at minus 70 degrees Celsius.
For transport to and at the site of administration it can be kept for up to five days at fridge temperatures, Sahin said, adding he was confident logistics would work very well.
âBy December we expect more data (on the molecular stability), and if those results allow us to keep the vaccine in a fridge for longer than five days, maybe two weeks, that would again simplify things.â
by Anonymous | reply 108 | November 9, 2020 4:21 PM |
That will be good for Pfizer, to have repeat business every year for another shot.
by Anonymous | reply 109 | November 9, 2020 4:24 PM |
I for one can't wait to take the mark of the Devil!
by Anonymous | reply 110 | November 9, 2020 4:26 PM |
According to Sahin, the vaccine should be able to last for at least a year. And these are cautious figures because how long-term immunity can be to the virus is currently unknown.
You don't have to be vaccinated if you don't want to be, r109.
by Anonymous | reply 111 | November 9, 2020 4:27 PM |
Behind Pfizer's vaccine, an understated husband-and-wife "dream team"
FRANKFURT (Reuters) - Positive data on BioNTech and U.S. partner Pfizer Incâs COVID-19 vaccine is an unlikely success for the married couple behind the German biotech firm, who have devoted their lives to harnessing the immune system against cancer.Pfizer said on Monday said its experimental vaccine was more than 90% effective in preventing COVID-19 based on initial data from a large study.
Pfizer and BioNTech are the first drugmakers to show successful data from a large-scale clinical trial of a coronavirus vaccine. The companies said they have so far found no serious safety concerns and expect to seek U.S. emergency use authorization later this month.
From humble roots as the son of a Turkish immigrant working at a Ford factory in Cologne, BioNTech Chief Executive Ugur Sahin, 55, now figures among the 100 richest Germans, together with his wife and fellow board member Oezlem Tuereci, 53, according to weekly Welt am Sonntag.
The market value of Nasdaq-listed BioNTech, which the pair co-founded, had ballooned to $21 billion as of Fridayâs close from $4.6 billion a year ago, with the firm set to play a major role in mass immunisation against the coronavirus.
âDespite his achievements, he never changed from being incredibly humble and personable,â said Matthias Kromayer, board member of venture capital firm MIG AG, whose funds have backed BioNTech since its inception in 2008.
He added Sahin would typically walk into business meetings wearing jeans and carrying his signature bicycle helmet and backpack with him.
Doggedly pursuing his childhood dream of studying medicine and becoming a physician, Sahin worked at teaching hospitals in Cologne and the southwestern city of Homburg, where he met Tuereci during his early academic career.
Medical research and oncology became a shared passion.
Tuereci, the daughter of a Turkish physician who had migrated to Germany, said in a media interview that even on the day of their wedding, both made time for lab work.
Together they honed in on the immune system as a potential ally in the fight against cancer and tried to address the unique genetic makeup of each tumour.
Life as entrepreneurs started in 2001 when they set up Ganymed Pharmaceuticals to develop cancer-fighting antibodies, but Sahin - by then a professor at Mainz university - never gave up academic research and teaching.
They won funding from MIG AG as well as from Thomas and Andreas Struengmann, who sold their generic drugs business Hexal to Novartis in 2005.
That venture was sold to Japanâs Astellas in 2016 for up to $1.4 billion. By then, the team behind Ganymed was already busy building BioNTech, founded in 2008, to pursue a much broader range of cancer immunotherapy tools.
That included mRNA, a versatile messenger substance to send genetic instructions into cells.
DREAM TEAM For MIGâs Kromayer, Tuereci and Sahin are a âdream teamâ in that they reconciled their visions with the constraints of reality.
The BioNTech story took a twist when Sahin in January came across a scientific paper on a new coronavirus outbreak in the Chinese city of Wuhan and it struck him how small the step was from anti-cancer mRNA drugs to mRNA-based viral vaccines.
BioNTech quickly assigned about 500 staff to project âlight speedâ to work on several possible compounds, winning pharma giant Pfizer and Chinese drugmaker Fosun as partners in March.
Matthias Theobald, a fellow oncology professor at Mainz university who has worked with Sahin for 20 years, said his tendency towards understatement belies a relentless ambition to transform medicine, exemplified by the leap of faith to a COVID-19 vaccine.
âHe is a very modest and humble person. Appearances mean little to him. But he wants to create the structures that allow him to realise his visions and thatâs where is aspirations are far from modest,â Theobald said.
[etc.]
by Anonymous | reply 112 | November 9, 2020 4:29 PM |
Not soon enough for Dr. Ben:
Sec. Ben Carson tested positive for COVID-19 this morning. His deputy chief of staff says he's "in good spirits & feels fortunate to have access to effective therapeutics which aid and markedly speed his recovery." Carson attended the election night party at the White House.
by Anonymous | reply 113 | November 9, 2020 4:30 PM |
A vaccine isn't going to help Ben Carson if he's already got COVID, R113.
by Anonymous | reply 114 | November 9, 2020 4:32 PM |
That's why I said the vaccine won't come soon enough for him, R114.
by Anonymous | reply 115 | November 9, 2020 4:34 PM |
Getting this virus under control is the best revenge we can get!
by Anonymous | reply 116 | November 9, 2020 4:35 PM |
Ah, okay, R115, I wasn't sure. Yeah, too late for Dr. Ben.
by Anonymous | reply 117 | November 9, 2020 4:36 PM |
R106, thanks to the research opportunities that Germany gave them, those Muslims happen to be among the 100 top richest people in Germany. So, no, you don't know anything about Germans.
by Anonymous | reply 118 | November 9, 2020 4:36 PM |
It seems like good news but I remain cautious and a bit skeptical. Iâll stick to my hygiene- and proximity- based prevention for now.
by Anonymous | reply 119 | November 9, 2020 4:37 PM |
You'll have to stick to that a good while after any vaccine starts getting disseminated, R119.
by Anonymous | reply 120 | November 9, 2020 4:39 PM |
Of course r119, there is no vaccination programme, that will take several months. Until then, We all need to carry on taking precautions and governments will still need to shut things down sometimes.
by Anonymous | reply 121 | November 9, 2020 4:39 PM |
I wonder if you can gain immunity from the semen of a vaccinated person?
by Anonymous | reply 122 | November 9, 2020 4:46 PM |
"Carson attended the election night party at the White House."
He was standing near the door and I handed him my coat!
by Anonymous | reply 123 | November 9, 2020 4:51 PM |
by Anonymous | reply 124 | November 9, 2020 4:55 PM |
Pfizer's mostly "American based".
by Anonymous | reply 125 | November 9, 2020 4:59 PM |
People with autoimmune disease need to wait to have this vaccine until it is tested on autoimmune patients. They don't know how their immune system will act.
by Anonymous | reply 126 | November 9, 2020 5:07 PM |
Great news for the country and the world. I hope the Biden administration creates a rapid distribution network once they release it to the public. This makes me almost as happy as the election outcome.
by Anonymous | reply 127 | November 9, 2020 5:08 PM |
Cannot wait time live in a normal country again!!!
YASS!
Can you guys believe some people have been OK with this disaster of a life in the US?
This last year has especially messed with me my head because I live around many of âthemâ, and guys, I have to tell you, it has been so rough.
I feel like crying. I am just so grateful to every one of us who said, âNo more! Basta!â
Not that Iâve ever taken our privileges for granted here such as voting, but I will never ever take anything we have for granted in the slightest.
This is such wonderful news and Iâm sending all of you bitches tight hugs and lots of love.
We did it. We got the madman out and can hold our heads up again. Like normal and decent Americans whjj OK care about each other & the world do.
by Anonymous | reply 128 | November 9, 2020 5:11 PM |
This is a German accomplishment. Let's not forget this.
by Anonymous | reply 129 | November 9, 2020 5:11 PM |
Well why didnât the Germans make this announcement, R129?
by Anonymous | reply 130 | November 9, 2020 5:15 PM |
I don't care who is claiming it. I'm happy we can see a light at the end of the tunnel. We olds have taken the brunt of this - from the number of deaths to the disparaging way we were dismissed as 'nothing' by the leadership of this country.
I don't want revenge. I want to get my starbucks every day, as promised, by that GOP snit.
by Anonymous | reply 131 | November 9, 2020 5:17 PM |
This announcement is effectively an update on the trials, r130. It's great news but it's more about public relations than announcing that something is available.
by Anonymous | reply 132 | November 9, 2020 5:25 PM |
This is the way the focus groups work for trials like these. The volunteers are split between those who receive the actual vaccine and those who receive a placebo. Both groups are tracked. In this case, there were 97 people who contacted Covid, and a huge percentage of those were in the placebo group. This is how they came up with the 90+% success rate. They also reported few side effects, which is also good news.
This is good news, and a light at the end of the tunnel. Most will not get the vaccine until next year. Still, we will not have to wear masks or social distance forever, which is great.
by Anonymous | reply 133 | November 9, 2020 5:27 PM |
[quote] My epidemiologist friends say this is interesting, but will need to see the results themselves, and that could take months.
âInterestingâ? Thatâs it? Are your epidemiologist friends quacks?
âInterestingâ is when a single person with HIV has a total bone marrow transplant and the virus is gone from their body. This is a bit more significant than âinterestingâ.
by Anonymous | reply 134 | November 9, 2020 5:32 PM |
Yes r129, the Germans did the research and vaccine development. Pfizer's role is primarily to help them scale it up, with mass trials, manufacturing and distribution. It's a great European-American achievement. We work better together.
by Anonymous | reply 135 | November 9, 2020 5:32 PM |
The Dow DOES NOT contain Futures prices...get it right. The Dow Jones Industrial Average is a stock market index.
by Anonymous | reply 136 | November 9, 2020 5:42 PM |
Calm down, R136.
by Anonymous | reply 137 | November 9, 2020 5:44 PM |
Before people throw accolades on a couple of researchers, letâs celebrate a team of researchers because vaccine development, especially one at this speed, is not the result of a couple of wealthy researchers. Letâs also give a shout-out to the study volunteers.
by Anonymous | reply 138 | November 9, 2020 6:16 PM |
Between this and Biden's win, holy fuck! Best November EVER!
by Anonymous | reply 139 | November 9, 2020 6:20 PM |
Is it okay to shoot cold water up under your skin? Must be excruciating.
by Anonymous | reply 140 | November 9, 2020 6:31 PM |
âthe vaccine was mostly developed in Germany by BioNTech, not by Pfizer in the US. In fact, it was developed by Muslim immigrants to Germany.â
It was developed by the company headed by the wonderful Turkish researcher-couple. However, itis a stretch to turn this scientific achievement into a play for politics by either sides of the political spectrum. Vaccine development is an insanely complex and drawn-out process that involves multiple stages and multiple specialist researchers along the way. It is most definitely not the singular work of two researchers who head the company which theyâd founded. As any scientist who works for private companies know, any discovery made while employed there are the property of those companies. The company itself and its governing members take credit for these breakthroughs. Same thing with any profit made from them.
by Anonymous | reply 141 | November 9, 2020 7:04 PM |
R24 you are a dense one aren't you, Hepatitis is three doses and I think is stored cold and seems to work just fine.
by Anonymous | reply 142 | November 9, 2020 7:07 PM |
[quote] It would be likely be ready to emergency use by end of the year but not ready to be distributed broadly until well into 2021.
What is emergency use? Theyâre going to give it to the people who are close to dying? What constitutes an emergency?
by Anonymous | reply 143 | November 9, 2020 7:13 PM |
Pence is blasting that this victory is theirs!
by Anonymous | reply 144 | November 9, 2020 7:15 PM |
R143 emergency use can be qualified as healthcare staff and frontline workers who have regular and frequent contact with members of the community at large. Obviously this is done to prevent spread among workers who are vital to social structure.
by Anonymous | reply 145 | November 9, 2020 7:19 PM |
This was a coordinated effort. No single country deserves all the credit.
by Anonymous | reply 146 | November 9, 2020 7:19 PM |
[quote] What is emergency use? Theyâre going to give it to the people who are close to dying? What constitutes an emergency?
It means people with vulnerable or with preexisting conditions will take it right away.
[quote] the Germans did the research and vaccine development. Pfizer's role is primarily to help them scale it up, with mass trials, manufacturing and distribution. It's a great European-American achievement.
Exactly, the research would not have been completed this quickly without Pfizer.
by Anonymous | reply 147 | November 9, 2020 7:22 PM |
R147 Emergency use could also mean for front line workers.
by Anonymous | reply 148 | November 9, 2020 7:25 PM |
[quote]Is it okay to shoot cold water up under your skin? Must be excruciating.
It's probably still better than drinking bleach.
by Anonymous | reply 149 | November 9, 2020 8:18 PM |
I was just watching CNN interview the CEO. It sounds very positive except for the manufacturing.
He said up to 1.3 billon doses could be made for 2021 (two dose vaccine). So 650 million patients.
On a world wide scale that isn't much.
Pfizer isn't the only one working on a vaccine of course, so hopefully the other companies have good results as well (and as capable manufacturing facilities).
by Anonymous | reply 150 | November 9, 2020 8:29 PM |
Thanks, Debbie Downer @ R150.
Now where do I sign up for this shit? I wanna beat the bum rush.
by Anonymous | reply 151 | November 9, 2020 10:34 PM |
I'll try to go on the grand rounds this week for our COVID-19 updates, I'm sure it'll be the topic of conversation. Maybe we'll have a better idea of who will be able to be immunized first and when that would happen. Hopefully we'll be able to be prioritized as recipients because we've been made to play Russian roulette with the flimsy surgical masks we've been told to use.
by Anonymous | reply 152 | November 9, 2020 10:56 PM |
Keep a close eye on the stock trades of Pfizer execs. That'll show how well the vaccine works (a sudden dump will reveal all).
by Anonymous | reply 153 | November 9, 2020 11:29 PM |
[quote] âOutta my way, poors
đđ
by Anonymous | reply 154 | November 10, 2020 12:11 AM |
a vocal crowdâwhich has drawn support from the anti-lockdown movement and other conspiratorial scenesâis already voicing its opposition to a coronavirus vaccine.
Now, she explained, anti-vaxxers are talking less about science and more about their âfreedomâ to refuse immunization. Blame a year full of lockdown opponents who claimed coronavirus protections, like masks and social distancing, were the pinnacle of government tyranny.
by Anonymous | reply 155 | November 10, 2020 12:40 AM |
[quote] I wonder if you can gain immunity from the semen of a vaccinated person?
Letâs one of us get vaccinated and together weâll check it out.
Ya know, strictly for data and research purposes.
by Anonymous | reply 156 | November 10, 2020 12:59 AM |
R155 Another issue where the far right and far left have found common ground.
by Anonymous | reply 157 | November 10, 2020 7:07 AM |
I don't know how Trump's position would embolden anti vaxxers since Trump has always tried to rush the vaccine. If given the choice, I'd take it right now. My experience is that 2020 has been utterly meaningless despite everyone trying to convince us that life is like normal.
by Anonymous | reply 158 | November 10, 2020 7:11 AM |
That's always been the case though, r150, that even after a vaccine is developed it will still take some time to get a mass vaccination programme together. Which is why the discussion is about giving it to key workers and vulnerable groups first.
The other good thing about these results though is that they are solid evidence that vaccines that use mRNA technology work, so other companies developing similar vaccines will possibly also have success and be able to manufacture even more doses of their own vaccine, so there will be a greater supply of vaccines altogether.
by Anonymous | reply 159 | November 10, 2020 7:35 AM |
R141, I wasn't claiming that this vaccine had been solely developed by two Muslims, I was just joking around because of the way the Trump administration seems to be trying to take credit for it.
by Anonymous | reply 160 | November 10, 2020 7:43 AM |
Two doses over a two month period? Ainât nobody got time for that! Pfizer really fucked up here.
by Anonymous | reply 161 | November 10, 2020 7:47 AM |
LOL, Jonathon Swan's father, who is a doctor/communicator who has been prominent on Australian TV and radio talking about Covid throughout the epidemic, just appeared on TV and said, in reference to the "bleach" crack: "I believe Donald Trump's treatment at Walter Reed was actually carried out by the cleaning lady."
by Anonymous | reply 162 | November 10, 2020 7:48 AM |
R159 is correct. I wouldnât be surprised if other potential vaccines will be announced in the coming weeks.
by Anonymous | reply 163 | November 10, 2020 8:27 AM |
Would it be possible to take two different kinds of the COVID vaccine?
by Anonymous | reply 164 | November 10, 2020 8:58 AM |
I wonât be taking this rushed vaccine until a year or two after it comes out because I donât trust it. I want to see if people have reactions to it.
by Anonymous | reply 165 | November 10, 2020 9:07 AM |
R164, yes. The original expectation was that all the late stage candidate vaccines would have lower efficacy so for many people that was the the plan, two different mechanism vaccines. If the 90% efficacy continues to pan out over time though this one might be good enough by itself.
R165 if you arenât elderly, in a congregate living facility or an employee of a medical institution youâll be at the back of the line anyway so youâll likely be waiting a year or more for access whether you want it or not.
My understanding is that the Oxford, Moderna and J&J vaccine studies should also be announcing interim results within the next few months. We will see if they are good or bad.
All of these vaccines are expensive and most of them have complicated logistics. IMHO government funding should start focusing candidates that are easier and cheaper to make and store next.
by Anonymous | reply 166 | November 10, 2020 10:55 AM |
R161, I believe most of the current vaccine candidates are based on 2 doses taken around 28 days apart.
by Anonymous | reply 167 | November 10, 2020 11:47 AM |
R153, There will be no real way to know the full safety profile until at least 2 years out. So, if stock starts getting dumped after 18 months, that would be the tip off that around year 3 theyâll finally announce âOh and it causes progressive blindnessâ or âchronic painâ or something. And theyâll be off the hook because it was such a great public service to even invent it.
by Anonymous | reply 168 | November 10, 2020 12:07 PM |
Noooooo!!!!!
by Anonymous | reply 169 | November 10, 2020 12:09 PM |
Moderna = two doses, 28 days apart
Pfizer = two doses, 21 days apart
Sanofi = no announcement
Novavax = two doses in phases 1 and 2; starting phase 3 this month
AstraZeneca = two doses, 28 days apart
Johnson & Johnson = testing both one and two doses in phase 3
by Anonymous | reply 170 | November 10, 2020 12:22 PM |
I'm already dreading having to choose which vaccine to get. I just know I'm going to pick the wrong one!
by Anonymous | reply 171 | November 10, 2020 12:28 PM |
Avoid J&J at all costs. Their safety trials are intentionally flawed.
by Anonymous | reply 172 | November 10, 2020 1:02 PM |
Even in the best of circumstances with this Pfizer vaccine, we're many months away from it actually being made available to the masses.
by Anonymous | reply 173 | November 10, 2020 1:18 PM |
There was a story on CNN this morning about the Pfizer vaccine: This vaccine has to be stored at -94 degrees Fahrenheit. Your Walgreens or your local clinic do hot have cold enough storage. The freezer can only be opened twice a day for one minute each time. Any longer and the vaccine is destroyed. The glass vials that contain the vaccine are extremely fragile at this temperature. Corning is working with Prifzer on developing a vial that won't break as easily at that low temperature.
There a lot of logistical problems associated with this particular vaccine.
by Anonymous | reply 174 | November 10, 2020 1:51 PM |
[quote] if you arenât elderly, in a congregate living facility or an employee of a medical institution youâll be at the back of the line anyway so youâll likely be waiting a year or more for access whether you want it or not.
Don't forget "wealthy." Because you know that rich people are going to get whatever they want, like they usually do.
by Anonymous | reply 175 | November 10, 2020 2:03 PM |
These are early trials. The vaccine has to be stored at like way below zero temps. Distribution will be costly and you'll need to get it in two doses every year. We need to keep trying. This is a good tart but we're not there yet.
by Anonymous | reply 176 | November 10, 2020 2:38 PM |
I'm ok with waiting. Thank you for the clarification on so much of this, Elderlez. I appreciate your calm and reasoned explanations.
by Anonymous | reply 177 | November 10, 2020 2:53 PM |
And yet AIDS remains with no cure? Funny how that works. When something is killing the majority theyâre Johnny On The Spot to get it cured. Itâll probably mutate and weâll have to get COVID shots every year.
by Anonymous | reply 178 | November 10, 2020 3:00 PM |
R178, this is not a "cure" for coronavirus.
by Anonymous | reply 179 | November 10, 2020 3:13 PM |
R179 better than nothing.
by Anonymous | reply 180 | November 10, 2020 3:36 PM |
We have made a ton of progress on HIV r178.
There is a pill you can take to prevent infection, and there are pills you can take to keep you viral load so low you can't even transmit it.
by Anonymous | reply 181 | November 10, 2020 3:40 PM |
It only took 30 years.
by Anonymous | reply 182 | November 10, 2020 3:47 PM |
Will you have to take it for the rest of your life?
by Anonymous | reply 183 | November 10, 2020 4:11 PM |
Yep. Like the flu shot.
by Anonymous | reply 184 | November 10, 2020 4:20 PM |
[quote] And yet AIDS remains with no cure? Funny how that works. When something is killing the majority theyâre Johnny On The Spot to get it cured. Itâll probably mutate and weâll have to get COVID shots every year.
Itâs called PrEP, shit for brains and no one dies from HIV anymore.
by Anonymous | reply 185 | November 10, 2020 4:21 PM |
690,000 died last year, which is significant lower than in the last but is not inconsequential. You sound like Trump, r185.
by Anonymous | reply 186 | November 10, 2020 4:29 PM |
I agree, R2. I've taken every precaution, and I've been fortunate enough not to have contracted it at this point. I spend most of my time alone (in true DL style, though not in a basement), so I'm hoping I'll continue to avoid it in the months to come, until the vaccine is tested on a wide variety of people, and we have some sort of results.
by Anonymous | reply 187 | November 10, 2020 5:02 PM |
Letâs face it it takes time to test a vaccine properly. All of a sudden a hardly tested vaccine is fine?
by Anonymous | reply 188 | November 10, 2020 6:29 PM |
[quote]Yep. Like the flu shot.
And just like the flu, it will have different strains and variants every year.
by Anonymous | reply 189 | November 10, 2020 6:47 PM |
The fact that these vaccines are aiming at the spike protein seems like it might not stay effective for very long. That is the part of the virus where most mutations occur.
I don't understand how they plan on getting this really fragile vaccine to people across America, let alone the world? I guess the rural second and third world, which lacks things like refrigeration, roads, and electricity, is just shit out of luck. Does it have to be kept so cold to keep the mRNA from replicating or breaking down the media it's in? Are there any other vaccines that need to be kept this cold? Anyone know?
by Anonymous | reply 190 | November 10, 2020 6:59 PM |
R190, this is the first human vaccine that will use mRNA as the delivery point.
by Anonymous | reply 191 | November 10, 2020 7:02 PM |
The Moderna vaccine has the same need for -80 freezers.
The rural and poor placed are unfortunately sol until a vaccine unless candidates like the Palese vaccine get funding for trials and then prove to be effective.
by Anonymous | reply 192 | November 10, 2020 7:27 PM |
[quote]And just like the flu, it will have different strains and variants every year.
You have no evidence to support that statement. It's a completely different type of virus from influenz.
by Anonymous | reply 193 | November 10, 2020 7:27 PM |
R184 You people get flu shots every year?
by Anonymous | reply 194 | November 10, 2020 7:28 PM |
Sorry for the typos and non-existent editing!
by Anonymous | reply 195 | November 10, 2020 7:55 PM |
R191 isnât that comforting. Sorry I have my doubts about this vaccine. The positive thing is, there isnât enough for everyone. Certainly not in the first batch. Iâll wait a bit longer, keep my distance and keep disinfecting.
R193 it already has mutated in minks and it has already transferred to people in Denmark.
R194 yes you need to because the virus mutates. Over here in Europe there is a SARS variant included in the vaccine as well. You have 40% less chance of catching the flu and if you do anyway you wonât get seriously ill.
by Anonymous | reply 196 | November 10, 2020 7:58 PM |
For R193
The new vaccine wonât work for this new strain
by Anonymous | reply 197 | November 10, 2020 8:01 PM |
Where in the article does it say that, R197?
by Anonymous | reply 198 | November 10, 2020 8:10 PM |
Viruses and vaccines are complicated things. It depends what part of the virus mutates and whether that section is the âtargetâ of the vaccine.
Results may vary.
by Anonymous | reply 199 | November 10, 2020 8:15 PM |
R198 if itâs anything like any other virus that mutates itâs unlikely one vaccine works for newer strains
by Anonymous | reply 200 | November 10, 2020 8:16 PM |
It's doesn't, R198. R197 didn't read the article. Just found something that talked about a mutation in the title and went with it.
For those of you thinking we'll be living with this until the end of time, when is the last time you worried about the virus that caused the 1918 pandemic? One way or another, humans adapt. This virus doesn't have a high enough mortality rate to end humanity. Wait to panic until that one shows up. Airborne ebola. Shit like that.
There are too many people crowding into to many new areas. We are melting ice and permafrost that has locked up bacteria and viruses that humans haven't seen in hundreds of thousands of years. The last time humanity truly faced eradication a couple thousand survived and repopulated the world. So, between environmental and geological disasters and new microbes, maybe a couple hundred thousand humans will survive the next extinction level event. We'll see. But it is coming.
by Anonymous | reply 201 | November 10, 2020 8:18 PM |
R196 I am from Croatia. Never met any grown up person that takes flu shots, especially not every year. Only children
by Anonymous | reply 202 | November 10, 2020 8:26 PM |
R202 Huh? Seriously? Over here itâs only the elderly and the sick that get it. Never children.
by Anonymous | reply 203 | November 10, 2020 8:27 PM |
Thatâs not entirely true there are genuine concerns it says and we will only know once itâs tested on people with a different strain R201
by Anonymous | reply 204 | November 10, 2020 8:34 PM |
Please...you first.
by Anonymous | reply 205 | November 10, 2020 8:46 PM |
R192, for some reason the large pharmaceuticals manufacturers were not convinced by what Palese is doing. He's apparently "pioneered genetics techniques that are used to make some of the billions of influenza vaccine doses produced annually, and his team has won millions of dollars to develop a universal flu jab", so it's not as though he doesn't have a credible research profile. But, for some reason, his technology didn't convince for this coronavirus.
Pfizer says that the -70 degrees temperatures for storage are currently precautionary and that may change over time. While I do hope that poorer countries can get access to this vaccine, what exactly do you expect the developers to do? Stop working on mRNA vaccines because they're hard to distribute in Africa? Besides, as we keep hearing, it's mainly Europe and the US that have really been hit by the virus and most poor countries are managing the situation ok with very few dead in comparison.
by Anonymous | reply 206 | November 10, 2020 8:48 PM |
Covid-19 shot accelerates vaccine technology
A look inside the groundbreaking mRNA science underpinning the BioNTech-Pfizer treatment
Clive Cookson in London and Joe Miller in Frankfurt 2 HOURS AGO
The news that BioNTech and Pfizerâs Covid-19 vaccine was more than 90 per cent effective in clinical trials has sparked new hope that vaccinations will provide a way out of the coronavirus pandemic.
âThe good message for mankind is that we now understand that Covid-19 can be prevented by a vaccine,â Ugur Sahin, BioNTechâs chief executive, said after the announcement.
The phase 3 trial still has to be completed and the data submitted to regulators for approval, but the initial results for the shot, which uses groundbreaking mRNA technology, were a significant milestone in the hunt of a vaccine.
How does it work? The mRNA technology, short for messenger RNA, is new to the vaccine scene. Conventional vaccines administer an inactivated virus, or proteins from that virus, into the body to trigger an immune response, which can prevent subsequent infection.
In contrast, mRNA technology â originally developed as a cancer therapy â injects genetic instructions into the body that tell cells to make viral proteins that prime the immune system. Although mRNA vaccines had been under development for several years for viruses including influenza, cytomegalovirus, HIV, rabies and Zika, the arrival of Covid-19 turbocharged the process.
An advantage of mRNA vaccines is that they are potentially faster to develop and easier to manufacture than some other technologies. Besides the Pfizer-BioNTech vaccine, other mRNA candidates for Covid-19 are under development at Moderna in the US, CureVac in Germany and Imperial College London in the UK.
Is mRNA technology safe? No vaccine can be guaranteed to be 100 per cent safe. But proponents of mRNA say it may be safer than alternative technologies, which introduce virus or viral proteins into the body and may provoke an unwanted reaction from the immune system.
Instead mRNA vaccines inject so-called lipid nanoparticles, which carry genetic instructions into the recipientâs cells. These microscopic droplets of oily liquid are very unlikely to be harmful.
One potential safety risk with any vaccine against a new virus is a phenomenon called antibody dependent enhancement. In ADE, the antibodies produced by a vaccine to fight infection actually exacerbate the effects of the virus.
Although ADE could yet occur in exceptional cases, it has not been observed in the tens of thousands of volunteers that have participated in phase 3 trials of coronavirus vaccines so far.
How will the vaccine be produced? While just 30 micrograms of BioNTechâs BNT162b2 vaccine are required per dose, it must be combined with the lipid nanoparticles that form a protective wrapping around the RNA.
The nanoparticle material is provided by companies such as Canadaâs Acuitas Therapeutics and is then processed in preapproved facilities owned by Pfizer and BioNTech across the US and Europe. Those facilities will be able to produce a combined 1.35bn doses by the end of next year, the companies have said.
BioNTech also acquired a manufacturing site in Marburg, Germany, in September from Swiss pharmaceutical group Novartis, which will increase its overall production capacity at some point next year.
While BioNTechâs existing facilities in Mainz produced the first batch of vaccines for clinical trials, most of the manufacturing will be done by Pfizer, which will produce and ship the vaccine worldwide. Doses for the EU, which is on the verge of signing a deal for 300m doses, will be manufactured primarily at Pfizerâs factory in Belgium.
How will it be distributed? At present, BioNTechâs vaccine must be stored at approximately minus 75 degrees Celsius while being transported, making it difficult to deliver to developing countries without robust logistics infrastructure.
by Anonymous | reply 207 | November 10, 2020 8:51 PM |
The vast majority of doses available in the next year, however, have already been bought by the US, EU and Japan, where shipping hypercold products is far easier.
Once it arrives in clinics, the vaccine â which can be kept at approximately minus 75C for up to six months â can survive in a normal fridge for up to 5 days.
Pfizer has said it will use a network of existing distribution centres in the US and elsewhere to make sure the product reaches hospitals and surgeries still frozen. The vaccine will be sent directly to these locations in so-called âthermal shippersâ that can carry between 200 and 1,000 vials each, and where the temperature will be constantly monitored by GPS, it said.
BioNTech said the freezing transport conditions, however, were just a âmatter of cautionâ and predicted further testing of the vaccine would show that some of those precautions can be relaxed in the future.
âI believe that upcoming stability data will support storage conditions that are not much different from any other vaccine,â said Mr Sahin.
How much will it cost? Unlike some of its rivals, BioNTech and Pfizer have not promised to supply the vaccine on a not-for-profit basis. In the US, the companies sold at least 100m doses to the government at $19.50 each, but the amounts paid by other countries â including the UK â have not been disclosed.
Ryan Richardson, chief strategy officer for BioNTech, told the FT Global Pharmaceutical and Biotechnology Conference on Tuesday that the company would adopt âdifferential pricingâ in different regions and price the vaccine âwell below typical market rates reflecting the situation that we're in and with the goal to ensure broad-based access around the worldâ.
Mr Richardson added that the company had invested more than $1bn to develop its innovative mRNA technology platform. âWhat weâve tried to do in this case is pursue a balanced approach that recognises that innovation requires capital and investment.â
by Anonymous | reply 208 | November 10, 2020 8:53 PM |
That's why they're culling the mink, r197.
by Anonymous | reply 209 | November 10, 2020 8:54 PM |
I know R209 but itâs not in time now, is it? You are right but itâs already out there. I believe 180k Danes are in strict lockdown now because of it. Letâs hope itâll work.
by Anonymous | reply 210 | November 10, 2020 9:07 PM |
Thank you, R166. From R164
by Anonymous | reply 211 | November 10, 2020 10:34 PM |
[quote] 690,000 died last year, which is significant lower than in the last but is not inconsequential. You sound like Trump, [R185].
In third world shitholes.
by Anonymous | reply 212 | November 10, 2020 11:39 PM |
[quote] There will be no real way to know the full safety profile until at least 2 years out. So, if stock starts getting dumped after 18 months, that would be the tip off that around year 3 theyâll finally announce âOh and it causes progressive blindnessâ or âchronic painâ or something. And theyâll be off the hook because it was such a great public service to even invent it.
This is not dragging on for 3 years, for godâs sake
by Anonymous | reply 213 | November 11, 2020 12:51 AM |
My pleasure R164 and good to see you oldlez.
by Anonymous | reply 214 | November 11, 2020 1:28 AM |
If it needs to be kept that cold, couldn't they just store it in Melania's poosey?
by Anonymous | reply 215 | November 11, 2020 1:35 AM |
But wouldn't it grow mushrooms in it from Old Yeller, R215?!
by Anonymous | reply 216 | November 11, 2020 2:22 AM |
I bet it ends up being a failure.
by Anonymous | reply 217 | November 11, 2020 2:22 AM |
University of Queensland just announced that its vaccine is showing an antibody response equivalent to that in people who have had the virus. It is still in testing like Pfizer's, but CSL is already manufacturing millions of doses in Melbourne.
by Anonymous | reply 218 | November 13, 2020 6:34 AM |
I'm not taking it.
by Anonymous | reply 219 | November 13, 2020 6:43 AM |
Hmm, die of COVID, or get The Walking Dead created viral "cure"?
by Anonymous | reply 220 | November 13, 2020 6:50 AM |
R208, it is going to cost around ÂŁ29 in the U.K. compared to about ÂŁ3 for the AstraZeneca vaccine which is only a few weeks from being ready apparently so because of storage logistic issues with the Pfizer vaccine it is likely that we will be offered the cheaper option in the U.K. although 10 million (5 million vaccines) have been ordered from Pfizer so some people are likely to get it. 40 million of the AstraZeneca one have been ordered so far.
by Anonymous | reply 221 | November 13, 2020 7:22 AM |
People whoâve had Covid also get reinfected. I read that a small group of people with very vulnerable health will get antibodies injected. The Dutch blood bank is working on that but they already said the antibody shots have to be repeated monthly. So I personally donât think the new vaccines will protect people very long.
by Anonymous | reply 222 | November 13, 2020 9:14 AM |
Well, R222, if you personally don't think so I guess they should just stop all vaccine development now. Well, that was a nice pipedream but R222 says it's not going to work.
Antibodies from other people die because you aren't replenishing them yourself. Vaccines make your own immune system create its own antibodies. You then get T-cells. They remember the invader after it has gone and after the antibodies, having done their job, disappear over time. When the invader shows up again, the T-cells send out the alarm and the antibody production begins again.
by Anonymous | reply 223 | November 13, 2020 9:38 AM |
Even Pfizer says their new vaccine only gives temporary immunity. We have to be patient for a decent vaccine to be developed. Itâs not rocket science R223.
by Anonymous | reply 224 | November 13, 2020 10:05 AM |
R224, you don't understand immunology OR rocket science. Just stop.
by Anonymous | reply 225 | November 13, 2020 10:20 AM |
R221, Bojo's government made a really bad deal if the BioNTech/Pfizer vaccine is going to cost ÂŁ29. The US has agreed to a lower price and the EU an even lower price.
There are still a lot of question marks about the Oxford vaccine and ÂŁ3 sounds way too cheap. It's just part of the Oxford efforts at marketing themselves. I think Moderna will be the next to announce, as they use the same mRNA technology as Pfizer.
by Anonymous | reply 226 | November 13, 2020 10:42 AM |
Lots of vaccines need boosters, r224 and new flu vaccines need to be developed each year.
by Anonymous | reply 227 | November 13, 2020 10:43 AM |
R221, I believe the UK has ordered 40 million doses of the Pfizer/BioNTech vaccine and 100 million doses of the as yet not ready AstraZeneca/Oxford vaccine.
by Anonymous | reply 228 | November 13, 2020 10:46 AM |
Oh, and the EU managed to get an order of 400 million doses of the AstraZeneca vaccine for about ÂŁ2 a dose. Let's see what happens with that one, though.
by Anonymous | reply 229 | November 13, 2020 10:48 AM |
'Take' vs 'get'. Perhaps it's a regional thing, like 'soda' vs 'pop'. I've always said 'I'm going to get the shot' or 'I got the shot', but now I hear 'take the shot' so much in the news. I thought that was a British expression, but apparently a lot of Americans say it too.
by Anonymous | reply 230 | November 13, 2020 10:49 AM |
R224 I think Iâll rely on experts rather than your feelings. Thanks.
by Anonymous | reply 231 | November 13, 2020 11:05 AM |
R226, I assume those prices are for the full vaccine of two shots each which would be half the price for each single dose.
by Anonymous | reply 232 | November 13, 2020 1:42 PM |
Side effects include hangover and face pain. Sounds great!
by Anonymous | reply 233 | November 14, 2020 6:20 AM |
Uh, no thanks. I hate hangovers.
by Anonymous | reply 234 | November 14, 2020 7:17 AM |
[post redacted because linking to dailymail.co.uk clearly indicates that the poster is either a troll or an idiot (probably both, honestly.) Our advice is that you just ignore this poster but whatever you do, don't click on any link to this putrid rag.]
by Anonymous | reply 235 | November 14, 2020 9:44 AM |
Once you get the vaccine, how long does it take the body to have 90% immunity from Covid? Is it immediate? And do you still need to wear a mask everywhere? How will we know who has had the vaccine and who hasn't once life starts to get back to normal? People will stop wearing masks and distancing at some point, but not all of those people will have been vaccinated.
by Anonymous | reply 236 | November 14, 2020 10:45 AM |
R236, from what I've read about the Pfizer vaccine, the 90% number came from one week after the second dose. Since getting infected and developing Covid takes at least a couple of days from exposure, I'd say a lot of that 90% protection was from the first dose which was 28 days before the second dose. The flu vaccine takes about two weeks to reach it's full level of protection.
That's all I can discern from what is currently publicly available. Make of it what you will.
by Anonymous | reply 237 | November 14, 2020 10:54 AM |
[quote] How will we know who has had the vaccine and who hasn't once life starts to get back to normal? People will stop wearing masks and distancing at some point, but not all of those people will have been vaccinated.
Admittedly I could be completely wrong here, but hereâs my understanding:
If youâre vaccinated you (theoretically) shouldnât get infected by someone else. So as long as Iâm vaccinated I donât care if you are or not because you canât make me sick, you can only get sick yourself.
Putting it another way, if youâve been vaccinated against, say rubella, you shouldnât get it, so if we pass in the street, it shouldnât matter that I have it to you.
Disclaimer: Iâm speaking theoretically, not actually since the efficacy hasnât been proven yet.
by Anonymous | reply 238 | November 14, 2020 3:09 PM |
A lot of people here don't seem to understand that the vaccine has a 90% efficacy rate, not that it is 90% effective, which isn't the same thing. The press reports have been very misleading about this.
In other words, if you receive the vaccine, you don't become 90% immune. Efficacy rate in this context means that if 100 people are vaccinated, 90 of them will receive immunity.
From Newsweek:
[quote]Of the 43,538 participants, 94 displayed symptoms of coronavirus indicating that the vaccine's efficacy rate is 90 percent, which represents the percentage of participants who received the vaccine and did not display symptoms.
The Newsweek article is linked below. Google "what does 90% effective mean pfizer vaccine" for more.
by Anonymous | reply 239 | November 14, 2020 7:43 PM |
So that means 10% of people who get the vaccine will have 0 protection. How will we know if weâre part of the 10%. I donât want to be going out all confident and maskless when in reality I have 0 protection.
by Anonymous | reply 240 | November 14, 2020 8:20 PM |
Its called herd immunity r240. If 90% of a population is immune you aren't going to have a virus spreading in a population.
by Anonymous | reply 241 | November 14, 2020 8:25 PM |
Plus, that 10% probably doesn't have zero immunity. They will, most likely, get a milder case if they do happen to get infected which will be difficult to do in a population where even 60-70% have immunity. (Accounting for the number of people who will refuse to get the vaccine.)
by Anonymous | reply 242 | November 15, 2020 12:34 AM |
But what happens when two 10%s get together.
by Anonymous | reply 243 | November 15, 2020 12:40 AM |
R243, most likely they won't have it because almost everyone around them will have immunity. That's what herd immunity is. There are portions of the the population now that can't get certain vaccines because of allergies, age, etc.. They are protected by the rest of us. There is a threshold, though. That's why there are starting to be outbreaks of measles and whooping cough again. Because the moronic anti-vaxxers are becoming numerous enough to affect herd immunity levels in certain communities.
by Anonymous | reply 244 | November 15, 2020 12:47 AM |
What happens if the 10% mutates into 8% death and 2% severe symptoms that make you wish you were dead? What about that??
Iâm not getting this failure of a âvaccine.â Nope.
by Anonymous | reply 245 | November 15, 2020 12:49 AM |
I don't think r245 understand how vaccines work.
by Anonymous | reply 246 | November 15, 2020 11:11 AM |
I don't think R246 understand [sic] how Datalounge works.
by Anonymous | reply 247 | November 15, 2020 11:29 AM |
How does Datalounge work, r247? People spout nonsense about vaccines and make a big deal about a typo?
by Anonymous | reply 248 | November 15, 2020 12:16 PM |
Sometimes the signifier for sarcasm can be found in the signature line.
Also, yes about making a big deal about typos.
by Anonymous | reply 249 | November 15, 2020 12:37 PM |
R243 There would only be a 1 in 100 chance of two "10%" people getting together, so the odds are good.
by Anonymous | reply 250 | November 15, 2020 1:31 PM |
But what if theyâre both at the bathhouse?!!
by Anonymous | reply 251 | November 15, 2020 6:38 PM |
It should be noted (but of course ignored because it destroys the narrative of every bigoted asshole) that BioNtech is not "German" in the traditional sense. It was founded by a Muslim immigrant scientist in Germany. I guess people only like to hear shit about them when it suits their bigotry. I hope they tell Donny and every bigot refuses to take it.
by Anonymous | reply 252 | November 15, 2020 6:55 PM |
So are the 40,000 people in the trial now running around without a mask and carrying on a normal to see if they still catch it or not?
by Anonymous | reply 253 | November 15, 2020 6:56 PM |
Moderna says their vaccine is 94,5% effective.
by Anonymous | reply 254 | November 16, 2020 4:21 PM |
[r254] And Moderna's vaccine doesn't have to be stored at extremely cold temperatures
by Anonymous | reply 255 | November 16, 2020 4:24 PM |
R253, the trial participants still don't know if they got the vaccine or the placebo (50% chance of each).
by Anonymous | reply 256 | November 16, 2020 4:28 PM |
Are the participants in the studies equally comprised of men and women? That has a huge bearing of the safety profile.
by Anonymous | reply 257 | November 16, 2020 4:31 PM |
R256 a vaccine thatâs 40% effective is like the flu vaccine. I suppose that wouldnât be an unlikely outcome for the new vaccine(s) either.
by Anonymous | reply 258 | November 16, 2020 4:55 PM |
so Pfizer's vaccine is 90% effective and has to be stored at -94°.
Moderna's vaccine is 94.7 effective and can be just refrigerated.
So is the next one going to be 100% and doesn't have to be refrigerated at all?
this all seems way too good to be true. Trump has really made his mark because who can trust any of them?
by Anonymous | reply 259 | November 16, 2020 4:59 PM |
Itâs good for the pharmaceutical industry too. Is it a coincidence Pfizerâs CEO sold stocks for 5.6 million a few days ago right after the announcement?
by Anonymous | reply 260 | November 16, 2020 5:53 PM |
Why is he offloading stocks? Is it a scam vaccine? If itâs real why not wait until the stocks go higher?
by Anonymous | reply 261 | November 16, 2020 6:19 PM |
He wasn't "offloading stock". It was a prearranged sale, which was triggered once the share price reached a certain level.
by Anonymous | reply 262 | November 16, 2020 6:21 PM |
I thought he dumped it because of the impending news about the better (more effective, less problematic storage) vaccine from Moderna would make Pfizer's less desirable.
by Anonymous | reply 263 | November 16, 2020 7:44 PM |
[quote]So are the 40,000 people in the trial now running around without a mask and carrying on a normal to see if they still catch it or not?
I'd assume they are or are not using masks the same way the general population is but the way the trial works is comparing the two groups (vaccine/placebo) infection rates to each other, not the general public.
by Anonymous | reply 264 | November 16, 2020 7:49 PM |
Except r263 his shares were automatically sold 7 days before the Moderna announcement.
by Anonymous | reply 265 | November 16, 2020 7:50 PM |
moderna's vaccine seen as nearly 95% effective in preventing infection
by Anonymous | reply 266 | November 16, 2020 7:53 PM |
[quote] this all seems way too good to be true.
I understand what you mean, but I saw something on one of the news networks that China theoretically had a vaccine in December but, the only way I can describe it is to say it wasnât ready. Whether that means tested, didnât work on this particular coronavirus or what, I donât know.
And there's been work on a coronavirus vaccine for years prior, so itâs not that unusual.
by Anonymous | reply 267 | November 16, 2020 8:04 PM |
We only have Miz Moderna's say-so.
I'm curbing my enthusiasm for the time being.
by Anonymous | reply 268 | November 16, 2020 8:05 PM |
R267 yes the SARS viruses we already knew but not COVID-19
by Anonymous | reply 269 | November 16, 2020 8:08 PM |
I'm not. I'm having great hope for a semi normal fall 2021.
by Anonymous | reply 270 | November 16, 2020 8:08 PM |
[quote] I understand what you mean, but I saw something on one of the news networks that China theoretically had a vaccine in December but, the only way I can describe it is to say it wasnât ready.
December isnât even here yet so theoretically it could be ready when they announce it next month.
by Anonymous | reply 271 | November 16, 2020 8:09 PM |
December of 2019, obviously.
by Anonymous | reply 272 | November 16, 2020 8:11 PM |
Iâm not getting this experimental vaccine. Iâll let you all be the guinea pigs. All I know is nobody better fuck with the handful of anti-retrovirals I take on a daily basis so I can accept daily anonymous loads.
by Anonymous | reply 273 | November 16, 2020 8:12 PM |
Yes, r269, that was the point. They had somewhat of a head start, so to speak.
by Anonymous | reply 274 | November 16, 2020 8:13 PM |
[quote] Iâll let you all be the guinea pigs.
Oh, hey, oh, whatâs wid the language, hah? Whatsa matta for you? You ainât gotta bring ethnicity into this, capisce?
by Anonymous | reply 275 | November 16, 2020 8:15 PM |
I've had the virus and am tempted to wait this out. It should be completely gone by the end of 2021/22. It will disappear like the Spanish flu did but not until after it takes many lives. Trump had it right but didn't understand the timeline and thought it would be gone before it did any harm.
by Anonymous | reply 276 | November 16, 2020 8:25 PM |
Furthermore r263, Moderna's success actually bolsters the Pfizer/BioNTech vaccine because it's further proof that the mRNA technology is effective and seemingly better than the more traditional vaccines being developed by Oxford, etc. Since BioNTech and Pfizer are doing lots of other work with mRNA, the strengthening credibility of mRNA can only be good for them.
by Anonymous | reply 277 | November 16, 2020 8:25 PM |
Trump had what right, r277?
by Anonymous | reply 278 | November 16, 2020 8:26 PM |
r278 that it would just disappear
by Anonymous | reply 279 | November 16, 2020 8:28 PM |
R279 true it happens with every pandemic.
by Anonymous | reply 280 | November 16, 2020 8:39 PM |
It's sad because the US has already paid Pfizer over $1 billion to get millions of doses of its vaccine. The US will spend billions more transporting and storing this vaccine at subzero temperatures--all the while, the Moderna vaccine only requires regular refrigeration.
by Anonymous | reply 281 | November 16, 2020 9:24 PM |
[quote] It will disappear like the Spanish flu did but not until after it takes many lives.
The Spanish flu didn't just disappear. There were strong measures in place at the time, especially with regards to mask wearing. Interesting, all the subsequent deadly flu pandemics (1957 and others after that), all were genetics variations that started with that original Spanish flu.
by Anonymous | reply 282 | November 16, 2020 9:26 PM |
[quote] true it happens with every pandemic.
Pandemics don't just disappear on their own--we actually take measures against them. We either eradicate the source or build up herd immunity (most strongly through vaccination). In every case, we have to be very active in order to get rid of it.
by Anonymous | reply 283 | November 16, 2020 9:29 PM |
R281, no single company will be able to produce enough vaccine for all so we need more than one and the supposed logistical difficulties of the Pfizer vaccine are way over-exaggerated.
by Anonymous | reply 284 | November 16, 2020 9:33 PM |
[quote] and the supposed logistical difficulties of the Pfizer vaccine are way over-exaggerated.
True. I just heard that itâs shipped in its own container that keeps it cold with dry ice. If necessary, you replace the dry ice.
by Anonymous | reply 285 | November 16, 2020 9:54 PM |
I only have 50 shares of Pfizer stock but I still canât understand why it hasnât gone up even when the announcement was made - whatâs up with this stock??
by Anonymous | reply 286 | November 16, 2020 9:59 PM |
[quote] Pfizer stock but I still canât understand why it hasnât gone up
Try their other pill, that may help.
by Anonymous | reply 287 | November 16, 2020 10:08 PM |
[quote] My epidemiologist friends say this is interesting, but will need to see the results themselves, and that could take months.
Now that Pfizerâs has been making the rounds to frontline healthcare workers and Modernaâs is about to be unleashed as well, what are your epidemiologist friends saying? Are they still finding it âinterestingâ?
by Anonymous | reply 288 | December 17, 2020 10:37 PM |
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