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Pfizer Says COVID Vaccine 90% Effective

Dow futures up over 1000 pts

Nice timing!

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by Anonymousreply 288December 17, 2020 10:37 PM

😂 As if Trump wasn’t depressed enough.

by Anonymousreply 1November 9, 2020 12:01 PM

Let other people be the guinea pigs.

by Anonymousreply 2November 9, 2020 12:01 PM

Trump will celebrate and take the W for the vaccine.

by Anonymousreply 3November 9, 2020 12:07 PM

Thanks for waiting a week, Pfizer! 😘

by Anonymousreply 4November 9, 2020 12:08 PM

[QUOTE] Trump will celebrate and take the W for the vaccine.

President Biden and his experts will be the one leading the efforts to distribute this vaccine.

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by Anonymousreply 5November 9, 2020 12:12 PM

damm right R5

Europe markets up 4%, Dow futures now up 1300 pts

by Anonymousreply 6November 9, 2020 12:14 PM

THEY WAITED A WEEK SO LEADER WOULD LOSE!!!!!!!

by Anonymousreply 7November 9, 2020 12:18 PM

This should be the top story in the news.

by Anonymousreply 8November 9, 2020 12:18 PM

Finally some good news! There's light at the end of the tunnel.

by Anonymousreply 9November 9, 2020 12:20 PM

How is this good news? What about the 10% of us?

by Anonymousreply 10November 9, 2020 12:26 PM

I told my friends the other day that there would likely be a vaccine before summer. I might have been right.

by Anonymousreply 11November 9, 2020 12:26 PM

Debbie Downer @ R10

by Anonymousreply 12November 9, 2020 12:28 PM

They waited a week because Dump and Jared would have fucked the population over on distribution while figuring out how they could first line their pockets.

by Anonymousreply 13November 9, 2020 12:30 PM

Do the 10% who aren’t “effective” die? If so, no thanks, it’s worse than my chances with Rona.

by Anonymousreply 14November 9, 2020 12:33 PM

What makes you think they waited a week? Maybe they just discovered it yesterday.

by Anonymousreply 15November 9, 2020 12:34 PM

Science r10

by Anonymousreply 16November 9, 2020 12:34 PM

Thanks Pfizer for not announcing last Monday!

by Anonymousreply 17November 9, 2020 12:37 PM

Really, R10? Are you that dense? It’s 90% effective against getting it, not protecting you from dying if you do get it. And getting even a mild case can pose all kinds of long term effects. But you do you.

by Anonymousreply 18November 9, 2020 12:41 PM

I meant R14.

by Anonymousreply 19November 9, 2020 12:41 PM

[quote] Do the 10% who aren’t “effective” die?

10% of the participants got the virus, but we know the fatality rate is now very low, so most will be okay.

by Anonymousreply 20November 9, 2020 12:42 PM

I have R14 blocked, most likely because she's a cunt and a troll.

by Anonymousreply 21November 9, 2020 12:44 PM

Check Ok?

by Anonymousreply 22November 9, 2020 12:45 PM

r18 not exactly. If it's effective in 90% of the population it'll pretty much create herd immunity. r10 is dense though.

by Anonymousreply 23November 9, 2020 12:49 PM

[quote] 10% of the participants got the virus, but we know the fatality rate is now very low, so most will be okay.

Why would you want to be the 10% who got the virus? Even if you won’t die. Pfizer really think they did something, didn’t they. No thanks, I’m good. I’ll wait til they come correct with a 💯% effective vaccine and they better come correct. Until then, fuck Pfizer.

by Anonymousreply 24November 9, 2020 12:54 PM

^LOL

by Anonymousreply 25November 9, 2020 12:57 PM

It's about as effective as the measles vaccine. Which is regarded as highly effective.

by Anonymousreply 26November 9, 2020 12:57 PM

[quote]10% of the participants got the virus

As a result of taking the vaccine?

by Anonymousreply 27November 9, 2020 12:59 PM

Isn’t the flu vaccine only 50% effective? In comparison, this sounds almost too good to be true.

by Anonymousreply 28November 9, 2020 1:00 PM

Congratulations to the German biotech company BioNTech that developed this vaccine. Pfizer were smart to choose to partner with them.

by Anonymousreply 29November 9, 2020 1:00 PM

I'm sitting at home with a bf who I'm almost certain has COVID, we're hopefully going to get a test today, it would just fucking figure that they'd have a vaccine out three weeks after he caught it.

by Anonymousreply 30November 9, 2020 1:00 PM

But the Oxford camp has warned that the effectiveness of the vaccine will decrease markedly in obese people. Fat whores bemoan!!!

by Anonymousreply 31November 9, 2020 1:01 PM

R30, the vaccine is not going to be out for many weeks, many months more likely.

by Anonymousreply 32November 9, 2020 1:01 PM

[QUOTE] But the Oxford camp has warned that the effectiveness of the vaccine will decrease markedly in obese people.

The effectiveness of everything decreases markedly in obese people.

by Anonymousreply 33November 9, 2020 1:03 PM

I guess the Republicans were right when they said all of this would end after they got Trump out of office. They're going to say this proves COVID was all a big plot to take him down and refuse to take it.

by Anonymousreply 34November 9, 2020 1:05 PM

Hey everyone, let the morons who say they won’t be vaccinated alone. We’ll be vaccinated!i know I know, they are a risk to the 10 percent for whom the vaccination will be effective, but they’re morons so who cares? Darwinism!

Vaccines that are 90 percent effective are considered very effective btw.

by Anonymousreply 35November 9, 2020 1:06 PM

90% effective, right because they have done such extensive testing.

Neurological symptoms are a side effect of the Oxford vaccine.

Across Europe the virus has mutated because of the mink farms and has been transferred to peoples. Well at least the farms will be closed within the next few months. The current vaccines they are working on don’t work on mutations.

I’m kind of sceptic about it all. Is it in any proven way effective or mainly money and business.

by Anonymousreply 36November 9, 2020 1:06 PM

people

by Anonymousreply 37November 9, 2020 1:07 PM

[quote] The effectiveness of everything decreases markedly in obese people.

Especially logic

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by Anonymousreply 38November 9, 2020 1:07 PM

[quote]Isn’t the flu vaccine only 50% effective? In comparison, this sounds almost too good to be true.

Keep in mind that this news was delivered in a press release, not a peer-reviewed medical journal, so the 90% figure might turn out to be a bit rosy. But wouldn't it be great?

[quote]President Biden and his experts will be the one leading the efforts to distribute this vaccine.

60 Minutes did a story last night on the army's efforts to gear up for distribution of the vaccine. It seems like they're on a good track.

by Anonymousreply 39November 9, 2020 1:08 PM

I would not take a vaccine developed under the Trump administration.

by Anonymousreply 40November 9, 2020 1:09 PM

If they are talking about infection rate then 90% effective means 90% fewer people in the treatment group got infected than the placebo group. If they are talking about disease severity then the disease severity was lessened by 90% in the treatment group. I don’t know which end point they are announcing, but either way great news.

by Anonymousreply 41November 9, 2020 1:10 PM

Is it 2-dose vaccine which has to be stored in a very cool place? Then human errors will fuck it all up again.

by Anonymousreply 42November 9, 2020 1:12 PM

It’s infections - extraordinarily wonderful news.

FWIW R40 Pfizer was the only company in phase 3 SARS-CoV-2 vaccine development who didn’t take BARDA money for the studies. They will be getting BARDA money for distribution however.

by Anonymousreply 43November 9, 2020 1:14 PM

"The analysis evaluated 94 confirmed Covid-19 infections among the trial’s 43,538 participants. Pfizer and the U.S. pharmaceutical giant’s German biotech partner said the case split between vaccinated individuals and those who received a placebo indicated a vaccine efficacy rate of above 90% at seven days after the second dose.

It means that protection from Covid-19 is achieved 28 days after the initial vaccination, which consists of a two-dose schedule.

The final vaccine efficacy percentage may vary, however, as safety and additional data continue to be collected."

by Anonymousreply 44November 9, 2020 1:15 PM

-80 freezers R42

by Anonymousreply 45November 9, 2020 1:15 PM

R36? Please tell me that English isn't your first language.

by Anonymousreply 46November 9, 2020 1:16 PM

Yes, we’d like to know the safety profile, including adverse events and permanent side effects.

by Anonymousreply 47November 9, 2020 1:16 PM

[quote] Do the 10% who aren’t “effective” die? If so, no thanks, it’s worse than my chances with Rona.

Yes. It means 1 out of every 10 who are given it will die of rapid onset old age. Here’s footage of the arrogant CEO of Pfizer taking the first dose:

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by Anonymousreply 48November 9, 2020 1:16 PM

[QUOTE] The final vaccine efficacy percentage may vary

In other words that 90% figure is probably bullshit.

by Anonymousreply 49November 9, 2020 1:17 PM

We have only Pfizer's hype--no other verification or confirmation.

They're pimping their stock.

by Anonymousreply 50November 9, 2020 1:18 PM

It’s better than What we have now which is absolutely nothing.

Oh and I have 52 Pfizer shares so yeah for that.

by Anonymousreply 51November 9, 2020 1:18 PM

[QUOTE] It’s better than What we have now which is absolutely nothing.

R51 probably owns stock in Pfizer. Admit it.

by Anonymousreply 52November 9, 2020 1:19 PM

R40, this vaccine has been developed under Chancellor Merkel (PhD in quantum chemistry) in Germany by BioNTech of Mainz. Pfizer is helping with the manufacturing and distribution.

by Anonymousreply 53November 9, 2020 1:20 PM

For the skeptical in New York, there is an extra layer of review.

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by Anonymousreply 54November 9, 2020 1:23 PM

[quote]Do the 10% who aren’t “effective” die? If so, no thanks, it’s worse than my chances with Rona.

Yes, Rose. The vaccine kills 10% of the people who take it. That's exactly how it works. :eyeroll:

by Anonymousreply 55November 9, 2020 1:24 PM

Didn't the Russian team also brag that their vaccine was 90% effective as well? Where is it now though? Putin must have tried it and got dementia as an adverse effect.

by Anonymousreply 56November 9, 2020 1:25 PM

Biden has named three physicians to head up the coronavirus task force. I have far more faith in them than I do in people like Mike Pence and Scott Atlas.

Imagine, real medical experts leading a pandemic response team. To steal a phrase from Ronald Reagan (yeeech), it really is 'Morning in America'

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by Anonymousreply 57November 9, 2020 1:27 PM

Needs to be stored in -80 degrees? Does it take 6 months to thaw it out? Or do they shoot into your arm REALLY cold?

by Anonymousreply 58November 9, 2020 1:27 PM

[quote]I would not take a vaccine developed under the Trump administration.

Good lord. It wasn't developed "under the Trump administration." He doesn't control everything on the planet, as much as he might wish he did.

by Anonymousreply 59November 9, 2020 1:29 PM

When they get a vaccine that's 99% or above effective, I'll get a puncture.

by Anonymousreply 60November 9, 2020 1:30 PM

R60, no vaccine is "99% or above effective." That's incredibly stupid of you.

by Anonymousreply 61November 9, 2020 1:33 PM

My epidemiologist friends say this is interesting, but will need to see the results themselves, and that could take months.

by Anonymousreply 62November 9, 2020 1:33 PM

[QUOTE] When they get a vaccine that's 99% or above effective, I'll get a puncture.

Maybe if you’d lower your standards, you’d get punctured a lot more often.

by Anonymousreply 63November 9, 2020 1:34 PM

While this is great news, I'm dreading Trump and his cult thinking he gets credit for this.

by Anonymousreply 64November 9, 2020 1:34 PM

[quote]When they get a vaccine that's 99% or above effective, I'll get a puncture

you're being silly, no vaccine is that effective, even for the chicken pox. at this speed if they get an vaccine that is around 80 percent efficacy then it would change the world

by Anonymousreply 65November 9, 2020 1:34 PM

Bident statement:

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by Anonymousreply 66November 9, 2020 1:38 PM

It's already started, R64.

[quote]STOCK MARKET UP BIG, VACCINE COMING SOON. REPORT 90% EFFECTIVE. SUCH GREAT NEWS!

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by Anonymousreply 67November 9, 2020 1:39 PM

[quote]I would not take a vaccine developed under the Trump administration.

Pfizer released a statement saying that they were not part of Trump's Operation Warp Speed.

by Anonymousreply 68November 9, 2020 1:40 PM

People are understandably clueless here. 90% effectice is incredible, everybody is shocked by these numbers.

Two things though

1) This daya hasn't gone through a thorough peer review yet

2) They aren't finished yet so it will likely drop someone.

Regardless anywhere close to 90% achieves herd immunity if this holds.

It would be likely be ready to emergency use by end of the year but not ready to be distributed broadly until well into 2021.

by Anonymousreply 69November 9, 2020 1:41 PM

Biden's language is purposeful r66, the scientist leading this effort at Pfizer is a woman.

by Anonymousreply 70November 9, 2020 1:42 PM

Merkel Vaccine! Rebrand now to cut Dump’s propaganda off at the knees.

by Anonymousreply 71November 9, 2020 1:43 PM

very good

by Anonymousreply 72November 9, 2020 1:44 PM

[QUOTE] Biden statement:

It will be nice to have the adults in charge again.

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by Anonymousreply 73November 9, 2020 1:46 PM

[quote] Regardless anywhere close to 90% achieves herd immunity if this holds.

The herd immunity people said we would never achieve.

by Anonymousreply 74November 9, 2020 2:01 PM

R67 I'm sure you and I aren't the only two who will celebrate the day when Dear Leader's tweets remain unreported in the media

by Anonymousreply 75November 9, 2020 2:02 PM

r74 Experts said that herd immunity could not be achieved through infections without a massive death toll. They were not talking about herd immunity achieved through vaccination. If enough anti-vaxxers refuse vaccination, it could still be difficult to achieve herd immunity.

by Anonymousreply 76November 9, 2020 2:13 PM

It still hasn't had the usual amount of length of testing? Emergency release cuts that down.

by Anonymousreply 77November 9, 2020 2:15 PM

R74, in the real world herd immunity can be achieved with mass vaccination. It can practically not be achieved by letting the virus spread as much as possible through the population in the hope that most people get it and then they will be immune, thus achieving "natural herd immunity" that way - which is what the no lockdown, no restrictions people were trying to claim.

by Anonymousreply 78November 9, 2020 2:26 PM

r74 was blocked

but if the numbers that roughly one quarter of NYers were positive for covid at one time, and the enormous death toll occurring there, for the whole of the country to gain herd immunity would require millions of deaths all across the country, a hecatomb

by Anonymousreply 79November 9, 2020 2:32 PM

I would prefer all these scientists work on building a time machine that can take us back to before Reagan was elected.

by Anonymousreply 80November 9, 2020 2:33 PM

Why did FB dump at the open?

by Anonymousreply 81November 9, 2020 2:33 PM

If Biden and Harris get the vaccine, I'm going to run to get it. I trust them.

by Anonymousreply 82November 9, 2020 2:34 PM

[quote]I would prefer all these scientists work on building a time machine that can take us back to before Reagan was elected.

You'd still have to live through the 80s again

by Anonymousreply 83November 9, 2020 2:38 PM

R83, I was a little kid in the 80s. All I really remember is Mr. Rogers and my dad throwing plates at the walls.

by Anonymousreply 84November 9, 2020 2:42 PM

[quote] The effectiveness of everything decreases markedly in obese people.

Not true. The effectiveness of donuts doesn’t.

by Anonymousreply 85November 9, 2020 2:47 PM

Please tell me you’re being sarcastic or are you that dumb?

The man said:

[quote] It’s better than What we have now which is absolutely nothing. [bold]Oh and I have 52 Pfizer shares so yeah for that.[/bold]

And you really

[quote][R51] probably owns stock in Pfizer. Admit it.

Really?

by Anonymousreply 86November 9, 2020 2:49 PM

*and you reply

by Anonymousreply 87November 9, 2020 2:49 PM

r81 Trump's Deplorables are moving to "uncensored" Parler. Trump's failure to concede defeat is probably causing even more Deplorables to leave Facebook.

by Anonymousreply 88November 9, 2020 2:50 PM

Correct r68. Pfizer was not part of Operation Warp Speed so the Trump administration cannot take any credit for this one.

Of course, they will anyway.

by Anonymousreply 89November 9, 2020 2:53 PM

Did G/R/Umpy come back and I wasn’t notified?

by Anonymousreply 90November 9, 2020 2:56 PM

R90, sadly, no. Umpy was, if nothing else, amusing.

by Anonymousreply 91November 9, 2020 2:57 PM

Even more importantly r89, the vaccine was mostly developed in Germany by BioNTech, not by Pfizer in the US. In fact, it was developed by Muslim immigrants to Germany.

by Anonymousreply 92November 9, 2020 2:57 PM

R92, it was invented by everything they hate! Science! Women! Muslims! Foreigners!

by Anonymousreply 93November 9, 2020 2:59 PM

What arethe negative effects? Besides your dick falling off?

by Anonymousreply 94November 9, 2020 3:13 PM

R24 No vaccine is 100% effective, most of our vaccines are around 80-95% effective. Also even if not fully preventative, the full extent of symptoms are lessened. There is a subset of people, very small minority who are vaccine non-responders, meaning they don’t develop antibodies as proof of immunity. But that’s a small percentage of the population, data varies but most state that it’s around 0.5-2-3%. Also just if you’re a non-responder to one vaccine/ vaccine series, it doesn’t mean it applies to all vaccines.

I found out I was a non-responder to the MMR vaccine series when I got my first job as RN, and I was tested for MMR immunity as part of employment health screening. Tested negative for measles immunity so I received another series. Still negative so they gave a another yet one more series. Negative again. They had to consult with CDC and was told that I shouldn’t receive any more MMR series (after 5 series in my lifetime), and I was counseled to be vigilant about not exposing myself to patients with suspected or diagnosed measles. I rely on herd immunity to not get measles, adults who get measles are likely to have a more serious course so not something I take lightly.

Now in my capacity as DNP I often counsel patients on the importance of vaccination and herd immunity. What is disappointing about the misinformation and mistrust of vaccine science is that many people have already decided against taking any COVID-19 vaccines out of fear. Fear that’s been stoked by politics.

by Anonymousreply 95November 9, 2020 3:15 PM

There absolutely are Pfizer run trials in the US in addition to Germany.

No to OWS on study funding, yes to OWS on distribution funding.

by Anonymousreply 96November 9, 2020 3:25 PM

We'll see how it goes. I don't have any confidence in this vaccine just off of an announcement by Pfizer.

by Anonymousreply 97November 9, 2020 3:48 PM

I'm not taking their fucking word for it.

by Anonymousreply 98November 9, 2020 3:50 PM

[quote] it was invented by everything they hate! Science! Women! Muslims! Foreigners!

Yeah, well those towel-heads invented the zero too! And then what did they have -- nothing!

by Anonymousreply 99November 9, 2020 3:53 PM

Zero is a commie Muslim conspiracy!

by Anonymousreply 100November 9, 2020 4:00 PM

Doesn't it take 1-2 years for FDA approval?

What are the long-term effects?

I think the rapture over this news should be muted.

by Anonymousreply 101November 9, 2020 4:09 PM

You won't have to take their word on it -- they'll undoubtably be publishing their results.

by Anonymousreply 102November 9, 2020 4:09 PM

Numbers’ in-cluding “zero” is a librul construck! I aint never trussed them dang thing’s! Look what numbers’ done did to my pressedant!!

by Anonymousreply 103November 9, 2020 4:12 PM

R101 not with Kessel on Biden’s CV19 team. Kessel is an evil bastard who should be in prison.

by Anonymousreply 104November 9, 2020 4:12 PM

If you think ‘bout it, zero doesn’t even exist. How can there be nuthin’ of something? If there wasn’t one of ‘em, you wouldn’t even have a name for it. Them Satanists been playing the long game since they done invented so-called math.

by Anonymousreply 105November 9, 2020 4:14 PM

[quote] the vaccine was mostly developed in Germany by BioNTech, not by Pfizer in the US. In fact, it was developed by Muslim immigrants to Germany.

Knowing how Germans will always be, it’s likely it was tested on Muslim immigrants in the German’s “experiments”.

by Anonymousreply 106November 9, 2020 4:17 PM

I've already had a 'vaccine'. It's called "Haditimmunenow"

by Anonymousreply 107November 9, 2020 4:19 PM

BioNTech hopes COVID-19 vaccine will immunize for at least a year

By Ludwig Burger, Patricia Weiss

FRANKFURT (Reuters) - BioNTech's BNTX.O co-founder and chief executive said he was optimistic that the protective effect of its experimental COVID-19 vaccine, co-developed with Pfizer PFE.N, would last for at least a year.

The two companies earlier on Monday became the first drugmakers to release successful trial data, saying their vaccine was shown to be more than 90% effective, a major victory in the fight against the pandemic.

“We should be more optimistic that the immunisation effect can last for at least a year,” CEO Ugur Sahin told Reuters.

While it was not yet known how long the protection would last, he said research on recovered patients had shown that those with high antibodies levels to begin with have not experienced a sharp drop in those levels, and the same would likely go for vaccinated people.

Highlighting the logistical challenge of distributing the vaccine, which belongs to a class known as messenger RNA, the arrangement for the first three months would be that the genetic compound would have to be shipped and centrally stored at minus 70 degrees Celsius.

For transport to and at the site of administration it can be kept for up to five days at fridge temperatures, Sahin said, adding he was confident logistics would work very well.

“By December we expect more data (on the molecular stability), and if those results allow us to keep the vaccine in a fridge for longer than five days, maybe two weeks, that would again simplify things.”

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by Anonymousreply 108November 9, 2020 4:21 PM

That will be good for Pfizer, to have repeat business every year for another shot.

by Anonymousreply 109November 9, 2020 4:24 PM

I for one can't wait to take the mark of the Devil!

by Anonymousreply 110November 9, 2020 4:26 PM

According to Sahin, the vaccine should be able to last for at least a year. And these are cautious figures because how long-term immunity can be to the virus is currently unknown.

You don't have to be vaccinated if you don't want to be, r109.

by Anonymousreply 111November 9, 2020 4:27 PM

Behind Pfizer's vaccine, an understated husband-and-wife "dream team"

FRANKFURT (Reuters) - Positive data on BioNTech and U.S. partner Pfizer Inc’s COVID-19 vaccine is an unlikely success for the married couple behind the German biotech firm, who have devoted their lives to harnessing the immune system against cancer.Pfizer said on Monday said its experimental vaccine was more than 90% effective in preventing COVID-19 based on initial data from a large study.

Pfizer and BioNTech are the first drugmakers to show successful data from a large-scale clinical trial of a coronavirus vaccine. The companies said they have so far found no serious safety concerns and expect to seek U.S. emergency use authorization later this month.

From humble roots as the son of a Turkish immigrant working at a Ford factory in Cologne, BioNTech Chief Executive Ugur Sahin, 55, now figures among the 100 richest Germans, together with his wife and fellow board member Oezlem Tuereci, 53, according to weekly Welt am Sonntag.

The market value of Nasdaq-listed BioNTech, which the pair co-founded, had ballooned to $21 billion as of Friday’s close from $4.6 billion a year ago, with the firm set to play a major role in mass immunisation against the coronavirus.

“Despite his achievements, he never changed from being incredibly humble and personable,” said Matthias Kromayer, board member of venture capital firm MIG AG, whose funds have backed BioNTech since its inception in 2008.

He added Sahin would typically walk into business meetings wearing jeans and carrying his signature bicycle helmet and backpack with him.

Doggedly pursuing his childhood dream of studying medicine and becoming a physician, Sahin worked at teaching hospitals in Cologne and the southwestern city of Homburg, where he met Tuereci during his early academic career.

Medical research and oncology became a shared passion.

Tuereci, the daughter of a Turkish physician who had migrated to Germany, said in a media interview that even on the day of their wedding, both made time for lab work.

Together they honed in on the immune system as a potential ally in the fight against cancer and tried to address the unique genetic makeup of each tumour.

Life as entrepreneurs started in 2001 when they set up Ganymed Pharmaceuticals to develop cancer-fighting antibodies, but Sahin - by then a professor at Mainz university - never gave up academic research and teaching.

They won funding from MIG AG as well as from Thomas and Andreas Struengmann, who sold their generic drugs business Hexal to Novartis in 2005.

That venture was sold to Japan’s Astellas in 2016 for up to $1.4 billion. By then, the team behind Ganymed was already busy building BioNTech, founded in 2008, to pursue a much broader range of cancer immunotherapy tools.

That included mRNA, a versatile messenger substance to send genetic instructions into cells.

DREAM TEAM For MIG’s Kromayer, Tuereci and Sahin are a “dream team” in that they reconciled their visions with the constraints of reality.

The BioNTech story took a twist when Sahin in January came across a scientific paper on a new coronavirus outbreak in the Chinese city of Wuhan and it struck him how small the step was from anti-cancer mRNA drugs to mRNA-based viral vaccines.

BioNTech quickly assigned about 500 staff to project “light speed” to work on several possible compounds, winning pharma giant Pfizer and Chinese drugmaker Fosun as partners in March.

Matthias Theobald, a fellow oncology professor at Mainz university who has worked with Sahin for 20 years, said his tendency towards understatement belies a relentless ambition to transform medicine, exemplified by the leap of faith to a COVID-19 vaccine.

“He is a very modest and humble person. Appearances mean little to him. But he wants to create the structures that allow him to realise his visions and that’s where is aspirations are far from modest,” Theobald said.

[etc.]

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by Anonymousreply 112November 9, 2020 4:29 PM

Not soon enough for Dr. Ben:

Sec. Ben Carson tested positive for COVID-19 this morning. His deputy chief of staff says he's "in good spirits & feels fortunate to have access to effective therapeutics which aid and markedly speed his recovery." Carson attended the election night party at the White House.

by Anonymousreply 113November 9, 2020 4:30 PM

A vaccine isn't going to help Ben Carson if he's already got COVID, R113.

by Anonymousreply 114November 9, 2020 4:32 PM

That's why I said the vaccine won't come soon enough for him, R114.

by Anonymousreply 115November 9, 2020 4:34 PM

Getting this virus under control is the best revenge we can get!

by Anonymousreply 116November 9, 2020 4:35 PM

Ah, okay, R115, I wasn't sure. Yeah, too late for Dr. Ben.

by Anonymousreply 117November 9, 2020 4:36 PM

R106, thanks to the research opportunities that Germany gave them, those Muslims happen to be among the 100 top richest people in Germany. So, no, you don't know anything about Germans.

by Anonymousreply 118November 9, 2020 4:36 PM

It seems like good news but I remain cautious and a bit skeptical. I’ll stick to my hygiene- and proximity- based prevention for now.

by Anonymousreply 119November 9, 2020 4:37 PM

You'll have to stick to that a good while after any vaccine starts getting disseminated, R119.

by Anonymousreply 120November 9, 2020 4:39 PM

Of course r119, there is no vaccination programme, that will take several months. Until then, We all need to carry on taking precautions and governments will still need to shut things down sometimes.

by Anonymousreply 121November 9, 2020 4:39 PM

I wonder if you can gain immunity from the semen of a vaccinated person?

by Anonymousreply 122November 9, 2020 4:46 PM

"Carson attended the election night party at the White House."

He was standing near the door and I handed him my coat!

by Anonymousreply 123November 9, 2020 4:51 PM
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by Anonymousreply 124November 9, 2020 4:55 PM

Pfizer's mostly "American based".

by Anonymousreply 125November 9, 2020 4:59 PM

People with autoimmune disease need to wait to have this vaccine until it is tested on autoimmune patients. They don't know how their immune system will act.

by Anonymousreply 126November 9, 2020 5:07 PM

Great news for the country and the world. I hope the Biden administration creates a rapid distribution network once they release it to the public. This makes me almost as happy as the election outcome.

by Anonymousreply 127November 9, 2020 5:08 PM

Cannot wait time live in a normal country again!!!

YASS!

Can you guys believe some people have been OK with this disaster of a life in the US?

This last year has especially messed with me my head because I live around many of “them”, and guys, I have to tell you, it has been so rough.

I feel like crying. I am just so grateful to every one of us who said, “No more! Basta!”

Not that I’ve ever taken our privileges for granted here such as voting, but I will never ever take anything we have for granted in the slightest.

This is such wonderful news and I’m sending all of you bitches tight hugs and lots of love.

We did it. We got the madman out and can hold our heads up again. Like normal and decent Americans whjj OK care about each other & the world do.

by Anonymousreply 128November 9, 2020 5:11 PM

This is a German accomplishment. Let's not forget this.

by Anonymousreply 129November 9, 2020 5:11 PM

Well why didn’t the Germans make this announcement, R129?

by Anonymousreply 130November 9, 2020 5:15 PM

I don't care who is claiming it. I'm happy we can see a light at the end of the tunnel. We olds have taken the brunt of this - from the number of deaths to the disparaging way we were dismissed as 'nothing' by the leadership of this country.

I don't want revenge. I want to get my starbucks every day, as promised, by that GOP snit.

by Anonymousreply 131November 9, 2020 5:17 PM

This announcement is effectively an update on the trials, r130. It's great news but it's more about public relations than announcing that something is available.

by Anonymousreply 132November 9, 2020 5:25 PM

This is the way the focus groups work for trials like these. The volunteers are split between those who receive the actual vaccine and those who receive a placebo. Both groups are tracked. In this case, there were 97 people who contacted Covid, and a huge percentage of those were in the placebo group. This is how they came up with the 90+% success rate. They also reported few side effects, which is also good news.

This is good news, and a light at the end of the tunnel. Most will not get the vaccine until next year. Still, we will not have to wear masks or social distance forever, which is great.

by Anonymousreply 133November 9, 2020 5:27 PM

[quote] My epidemiologist friends say this is interesting, but will need to see the results themselves, and that could take months.

“Interesting”? That’s it? Are your epidemiologist friends quacks?

“Interesting” is when a single person with HIV has a total bone marrow transplant and the virus is gone from their body. This is a bit more significant than “interesting”.

by Anonymousreply 134November 9, 2020 5:32 PM

Yes r129, the Germans did the research and vaccine development. Pfizer's role is primarily to help them scale it up, with mass trials, manufacturing and distribution. It's a great European-American achievement. We work better together.

by Anonymousreply 135November 9, 2020 5:32 PM

The Dow DOES NOT contain Futures prices...get it right. The Dow Jones Industrial Average is a stock market index.

by Anonymousreply 136November 9, 2020 5:42 PM

Calm down, R136.

by Anonymousreply 137November 9, 2020 5:44 PM

Before people throw accolades on a couple of researchers, let’s celebrate a team of researchers because vaccine development, especially one at this speed, is not the result of a couple of wealthy researchers. Let’s also give a shout-out to the study volunteers.

by Anonymousreply 138November 9, 2020 6:16 PM

Between this and Biden's win, holy fuck! Best November EVER!

by Anonymousreply 139November 9, 2020 6:20 PM

Is it okay to shoot cold water up under your skin? Must be excruciating.

by Anonymousreply 140November 9, 2020 6:31 PM

“the vaccine was mostly developed in Germany by BioNTech, not by Pfizer in the US. In fact, it was developed by Muslim immigrants to Germany.”

It was developed by the company headed by the wonderful Turkish researcher-couple. However, itis a stretch to turn this scientific achievement into a play for politics by either sides of the political spectrum. Vaccine development is an insanely complex and drawn-out process that involves multiple stages and multiple specialist researchers along the way. It is most definitely not the singular work of two researchers who head the company which they’d founded. As any scientist who works for private companies know, any discovery made while employed there are the property of those companies. The company itself and its governing members take credit for these breakthroughs. Same thing with any profit made from them.

by Anonymousreply 141November 9, 2020 7:04 PM

R24 you are a dense one aren't you, Hepatitis is three doses and I think is stored cold and seems to work just fine.

by Anonymousreply 142November 9, 2020 7:07 PM

[quote] It would be likely be ready to emergency use by end of the year but not ready to be distributed broadly until well into 2021.

What is emergency use? They’re going to give it to the people who are close to dying? What constitutes an emergency?

by Anonymousreply 143November 9, 2020 7:13 PM

Pence is blasting that this victory is theirs!

by Anonymousreply 144November 9, 2020 7:15 PM

R143 emergency use can be qualified as healthcare staff and frontline workers who have regular and frequent contact with members of the community at large. Obviously this is done to prevent spread among workers who are vital to social structure.

by Anonymousreply 145November 9, 2020 7:19 PM

This was a coordinated effort. No single country deserves all the credit.

by Anonymousreply 146November 9, 2020 7:19 PM

[quote] What is emergency use? They’re going to give it to the people who are close to dying? What constitutes an emergency?

It means people with vulnerable or with preexisting conditions will take it right away.

[quote] the Germans did the research and vaccine development. Pfizer's role is primarily to help them scale it up, with mass trials, manufacturing and distribution. It's a great European-American achievement.

Exactly, the research would not have been completed this quickly without Pfizer.

by Anonymousreply 147November 9, 2020 7:22 PM

R147 Emergency use could also mean for front line workers.

by Anonymousreply 148November 9, 2020 7:25 PM

[quote]Is it okay to shoot cold water up under your skin? Must be excruciating.

It's probably still better than drinking bleach.

by Anonymousreply 149November 9, 2020 8:18 PM

I was just watching CNN interview the CEO. It sounds very positive except for the manufacturing.

He said up to 1.3 billon doses could be made for 2021 (two dose vaccine). So 650 million patients.

On a world wide scale that isn't much.

Pfizer isn't the only one working on a vaccine of course, so hopefully the other companies have good results as well (and as capable manufacturing facilities).

by Anonymousreply 150November 9, 2020 8:29 PM

Thanks, Debbie Downer @ R150.

Now where do I sign up for this shit? I wanna beat the bum rush.

by Anonymousreply 151November 9, 2020 10:34 PM

I'll try to go on the grand rounds this week for our COVID-19 updates, I'm sure it'll be the topic of conversation. Maybe we'll have a better idea of who will be able to be immunized first and when that would happen. Hopefully we'll be able to be prioritized as recipients because we've been made to play Russian roulette with the flimsy surgical masks we've been told to use.

by Anonymousreply 152November 9, 2020 10:56 PM

Keep a close eye on the stock trades of Pfizer execs. That'll show how well the vaccine works (a sudden dump will reveal all).

by Anonymousreply 153November 9, 2020 11:29 PM

[quote] —Outta my way, poors

😂😂

by Anonymousreply 154November 10, 2020 12:11 AM

a vocal crowd—which has drawn support from the anti-lockdown movement and other conspiratorial scenes—is already voicing its opposition to a coronavirus vaccine.

Now, she explained, anti-vaxxers are talking less about science and more about their “freedom” to refuse immunization. Blame a year full of lockdown opponents who claimed coronavirus protections, like masks and social distancing, were the pinnacle of government tyranny.

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by Anonymousreply 155November 10, 2020 12:40 AM

[quote] I wonder if you can gain immunity from the semen of a vaccinated person?

Let’s one of us get vaccinated and together we’ll check it out.

Ya know, strictly for data and research purposes.

by Anonymousreply 156November 10, 2020 12:59 AM

R155 Another issue where the far right and far left have found common ground.

by Anonymousreply 157November 10, 2020 7:07 AM

I don't know how Trump's position would embolden anti vaxxers since Trump has always tried to rush the vaccine. If given the choice, I'd take it right now. My experience is that 2020 has been utterly meaningless despite everyone trying to convince us that life is like normal.

by Anonymousreply 158November 10, 2020 7:11 AM

That's always been the case though, r150, that even after a vaccine is developed it will still take some time to get a mass vaccination programme together. Which is why the discussion is about giving it to key workers and vulnerable groups first.

The other good thing about these results though is that they are solid evidence that vaccines that use mRNA technology work, so other companies developing similar vaccines will possibly also have success and be able to manufacture even more doses of their own vaccine, so there will be a greater supply of vaccines altogether.

by Anonymousreply 159November 10, 2020 7:35 AM

R141, I wasn't claiming that this vaccine had been solely developed by two Muslims, I was just joking around because of the way the Trump administration seems to be trying to take credit for it.

by Anonymousreply 160November 10, 2020 7:43 AM

Two doses over a two month period? Ain’t nobody got time for that! Pfizer really fucked up here.

by Anonymousreply 161November 10, 2020 7:47 AM

LOL, Jonathon Swan's father, who is a doctor/communicator who has been prominent on Australian TV and radio talking about Covid throughout the epidemic, just appeared on TV and said, in reference to the "bleach" crack: "I believe Donald Trump's treatment at Walter Reed was actually carried out by the cleaning lady."

by Anonymousreply 162November 10, 2020 7:48 AM

R159 is correct. I wouldn’t be surprised if other potential vaccines will be announced in the coming weeks.

by Anonymousreply 163November 10, 2020 8:27 AM

Would it be possible to take two different kinds of the COVID vaccine?

by Anonymousreply 164November 10, 2020 8:58 AM

I won’t be taking this rushed vaccine until a year or two after it comes out because I don’t trust it. I want to see if people have reactions to it.

by Anonymousreply 165November 10, 2020 9:07 AM

R164, yes. The original expectation was that all the late stage candidate vaccines would have lower efficacy so for many people that was the the plan, two different mechanism vaccines. If the 90% efficacy continues to pan out over time though this one might be good enough by itself.

R165 if you aren’t elderly, in a congregate living facility or an employee of a medical institution you’ll be at the back of the line anyway so you’ll likely be waiting a year or more for access whether you want it or not.

My understanding is that the Oxford, Moderna and J&J vaccine studies should also be announcing interim results within the next few months. We will see if they are good or bad.

All of these vaccines are expensive and most of them have complicated logistics. IMHO government funding should start focusing candidates that are easier and cheaper to make and store next.

by Anonymousreply 166November 10, 2020 10:55 AM

R161, I believe most of the current vaccine candidates are based on 2 doses taken around 28 days apart.

by Anonymousreply 167November 10, 2020 11:47 AM

R153, There will be no real way to know the full safety profile until at least 2 years out. So, if stock starts getting dumped after 18 months, that would be the tip off that around year 3 they’ll finally announce “Oh and it causes progressive blindness” or “chronic pain” or something. And they’ll be off the hook because it was such a great public service to even invent it.

by Anonymousreply 168November 10, 2020 12:07 PM

Noooooo!!!!!

by Anonymousreply 169November 10, 2020 12:09 PM

Moderna = two doses, 28 days apart

Pfizer = two doses, 21 days apart

Sanofi = no announcement

Novavax = two doses in phases 1 and 2; starting phase 3 this month

AstraZeneca = two doses, 28 days apart

Johnson & Johnson = testing both one and two doses in phase 3

by Anonymousreply 170November 10, 2020 12:22 PM

I'm already dreading having to choose which vaccine to get. I just know I'm going to pick the wrong one!

by Anonymousreply 171November 10, 2020 12:28 PM

Avoid J&J at all costs. Their safety trials are intentionally flawed.

by Anonymousreply 172November 10, 2020 1:02 PM

Even in the best of circumstances with this Pfizer vaccine, we're many months away from it actually being made available to the masses.

by Anonymousreply 173November 10, 2020 1:18 PM

There was a story on CNN this morning about the Pfizer vaccine: This vaccine has to be stored at -94 degrees Fahrenheit. Your Walgreens or your local clinic do hot have cold enough storage. The freezer can only be opened twice a day for one minute each time. Any longer and the vaccine is destroyed. The glass vials that contain the vaccine are extremely fragile at this temperature. Corning is working with Prifzer on developing a vial that won't break as easily at that low temperature.

There a lot of logistical problems associated with this particular vaccine.

by Anonymousreply 174November 10, 2020 1:51 PM

[quote] if you aren’t elderly, in a congregate living facility or an employee of a medical institution you’ll be at the back of the line anyway so you’ll likely be waiting a year or more for access whether you want it or not.

Don't forget "wealthy." Because you know that rich people are going to get whatever they want, like they usually do.

by Anonymousreply 175November 10, 2020 2:03 PM

These are early trials. The vaccine has to be stored at like way below zero temps. Distribution will be costly and you'll need to get it in two doses every year. We need to keep trying. This is a good tart but we're not there yet.

by Anonymousreply 176November 10, 2020 2:38 PM

I'm ok with waiting. Thank you for the clarification on so much of this, Elderlez. I appreciate your calm and reasoned explanations.

by Anonymousreply 177November 10, 2020 2:53 PM

And yet AIDS remains with no cure? Funny how that works. When something is killing the majority they’re Johnny On The Spot to get it cured. It’ll probably mutate and we’ll have to get COVID shots every year.

by Anonymousreply 178November 10, 2020 3:00 PM

R178, this is not a "cure" for coronavirus.

by Anonymousreply 179November 10, 2020 3:13 PM

R179 better than nothing.

by Anonymousreply 180November 10, 2020 3:36 PM

We have made a ton of progress on HIV r178.

There is a pill you can take to prevent infection, and there are pills you can take to keep you viral load so low you can't even transmit it.

by Anonymousreply 181November 10, 2020 3:40 PM

It only took 30 years.

by Anonymousreply 182November 10, 2020 3:47 PM

Will you have to take it for the rest of your life?

by Anonymousreply 183November 10, 2020 4:11 PM

Yep. Like the flu shot.

by Anonymousreply 184November 10, 2020 4:20 PM

[quote] And yet AIDS remains with no cure? Funny how that works. When something is killing the majority they’re Johnny On The Spot to get it cured. It’ll probably mutate and we’ll have to get COVID shots every year.

It’s called PrEP, shit for brains and no one dies from HIV anymore.

by Anonymousreply 185November 10, 2020 4:21 PM

690,000 died last year, which is significant lower than in the last but is not inconsequential. You sound like Trump, r185.

by Anonymousreply 186November 10, 2020 4:29 PM

I agree, R2. I've taken every precaution, and I've been fortunate enough not to have contracted it at this point. I spend most of my time alone (in true DL style, though not in a basement), so I'm hoping I'll continue to avoid it in the months to come, until the vaccine is tested on a wide variety of people, and we have some sort of results.

by Anonymousreply 187November 10, 2020 5:02 PM

Let’s face it it takes time to test a vaccine properly. All of a sudden a hardly tested vaccine is fine?

by Anonymousreply 188November 10, 2020 6:29 PM

[quote]Yep. Like the flu shot.

And just like the flu, it will have different strains and variants every year.

by Anonymousreply 189November 10, 2020 6:47 PM

The fact that these vaccines are aiming at the spike protein seems like it might not stay effective for very long. That is the part of the virus where most mutations occur.

I don't understand how they plan on getting this really fragile vaccine to people across America, let alone the world? I guess the rural second and third world, which lacks things like refrigeration, roads, and electricity, is just shit out of luck. Does it have to be kept so cold to keep the mRNA from replicating or breaking down the media it's in? Are there any other vaccines that need to be kept this cold? Anyone know?

by Anonymousreply 190November 10, 2020 6:59 PM

R190, this is the first human vaccine that will use mRNA as the delivery point.

by Anonymousreply 191November 10, 2020 7:02 PM

The Moderna vaccine has the same need for -80 freezers.

The rural and poor placed are unfortunately sol until a vaccine unless candidates like the Palese vaccine get funding for trials and then prove to be effective.

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by Anonymousreply 192November 10, 2020 7:27 PM

[quote]And just like the flu, it will have different strains and variants every year.

You have no evidence to support that statement. It's a completely different type of virus from influenz.

by Anonymousreply 193November 10, 2020 7:27 PM

R184 You people get flu shots every year?

by Anonymousreply 194November 10, 2020 7:28 PM

Sorry for the typos and non-existent editing!

by Anonymousreply 195November 10, 2020 7:55 PM

R191 isn’t that comforting. Sorry I have my doubts about this vaccine. The positive thing is, there isn’t enough for everyone. Certainly not in the first batch. I’ll wait a bit longer, keep my distance and keep disinfecting.

R193 it already has mutated in minks and it has already transferred to people in Denmark.

R194 yes you need to because the virus mutates. Over here in Europe there is a SARS variant included in the vaccine as well. You have 40% less chance of catching the flu and if you do anyway you won’t get seriously ill.

by Anonymousreply 196November 10, 2020 7:58 PM

For R193

The new vaccine won’t work for this new strain

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by Anonymousreply 197November 10, 2020 8:01 PM

Where in the article does it say that, R197?

by Anonymousreply 198November 10, 2020 8:10 PM

Viruses and vaccines are complicated things. It depends what part of the virus mutates and whether that section is the “target” of the vaccine.

Results may vary.

by Anonymousreply 199November 10, 2020 8:15 PM

R198 if it’s anything like any other virus that mutates it’s unlikely one vaccine works for newer strains

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by Anonymousreply 200November 10, 2020 8:16 PM

It's doesn't, R198. R197 didn't read the article. Just found something that talked about a mutation in the title and went with it.

For those of you thinking we'll be living with this until the end of time, when is the last time you worried about the virus that caused the 1918 pandemic? One way or another, humans adapt. This virus doesn't have a high enough mortality rate to end humanity. Wait to panic until that one shows up. Airborne ebola. Shit like that.

There are too many people crowding into to many new areas. We are melting ice and permafrost that has locked up bacteria and viruses that humans haven't seen in hundreds of thousands of years. The last time humanity truly faced eradication a couple thousand survived and repopulated the world. So, between environmental and geological disasters and new microbes, maybe a couple hundred thousand humans will survive the next extinction level event. We'll see. But it is coming.

by Anonymousreply 201November 10, 2020 8:18 PM

R196 I am from Croatia. Never met any grown up person that takes flu shots, especially not every year. Only children

by Anonymousreply 202November 10, 2020 8:26 PM

R202 Huh? Seriously? Over here it’s only the elderly and the sick that get it. Never children.

by Anonymousreply 203November 10, 2020 8:27 PM

That’s not entirely true there are genuine concerns it says and we will only know once it’s tested on people with a different strain R201

by Anonymousreply 204November 10, 2020 8:34 PM

Please...you first.

by Anonymousreply 205November 10, 2020 8:46 PM

R192, for some reason the large pharmaceuticals manufacturers were not convinced by what Palese is doing. He's apparently "pioneered genetics techniques that are used to make some of the billions of influenza vaccine doses produced annually, and his team has won millions of dollars to develop a universal flu jab", so it's not as though he doesn't have a credible research profile. But, for some reason, his technology didn't convince for this coronavirus.

Pfizer says that the -70 degrees temperatures for storage are currently precautionary and that may change over time. While I do hope that poorer countries can get access to this vaccine, what exactly do you expect the developers to do? Stop working on mRNA vaccines because they're hard to distribute in Africa? Besides, as we keep hearing, it's mainly Europe and the US that have really been hit by the virus and most poor countries are managing the situation ok with very few dead in comparison.

by Anonymousreply 206November 10, 2020 8:48 PM

Covid-19 shot accelerates vaccine technology

A look inside the groundbreaking mRNA science underpinning the BioNTech-Pfizer treatment

Clive Cookson in London and Joe Miller in Frankfurt 2 HOURS AGO

The news that BioNTech and Pfizer’s Covid-19 vaccine was more than 90 per cent effective in clinical trials has sparked new hope that vaccinations will provide a way out of the coronavirus pandemic.

“The good message for mankind is that we now understand that Covid-19 can be prevented by a vaccine,” Ugur Sahin, BioNTech’s chief executive, said after the announcement.

The phase 3 trial still has to be completed and the data submitted to regulators for approval, but the initial results for the shot, which uses groundbreaking mRNA technology, were a significant milestone in the hunt of a vaccine.

How does it work? The mRNA technology, short for messenger RNA, is new to the vaccine scene. Conventional vaccines administer an inactivated virus, or proteins from that virus, into the body to trigger an immune response, which can prevent subsequent infection.

In contrast, mRNA technology — originally developed as a cancer therapy — injects genetic instructions into the body that tell cells to make viral proteins that prime the immune system. Although mRNA vaccines had been under development for several years for viruses including influenza, cytomegalovirus, HIV, rabies and Zika, the arrival of Covid-19 turbocharged the process.

An advantage of mRNA vaccines is that they are potentially faster to develop and easier to manufacture than some other technologies. Besides the Pfizer-BioNTech vaccine, other mRNA candidates for Covid-19 are under development at Moderna in the US, CureVac in Germany and Imperial College London in the UK.

Is mRNA technology safe? No vaccine can be guaranteed to be 100 per cent safe. But proponents of mRNA say it may be safer than alternative technologies, which introduce virus or viral proteins into the body and may provoke an unwanted reaction from the immune system.

Instead mRNA vaccines inject so-called lipid nanoparticles, which carry genetic instructions into the recipient’s cells. These microscopic droplets of oily liquid are very unlikely to be harmful.

One potential safety risk with any vaccine against a new virus is a phenomenon called antibody dependent enhancement. In ADE, the antibodies produced by a vaccine to fight infection actually exacerbate the effects of the virus.

Although ADE could yet occur in exceptional cases, it has not been observed in the tens of thousands of volunteers that have participated in phase 3 trials of coronavirus vaccines so far.

How will the vaccine be produced? While just 30 micrograms of BioNTech’s BNT162b2 vaccine are required per dose, it must be combined with the lipid nanoparticles that form a protective wrapping around the RNA.

The nanoparticle material is provided by companies such as Canada’s Acuitas Therapeutics and is then processed in preapproved facilities owned by Pfizer and BioNTech across the US and Europe. Those facilities will be able to produce a combined 1.35bn doses by the end of next year, the companies have said.

BioNTech also acquired a manufacturing site in Marburg, Germany, in September from Swiss pharmaceutical group Novartis, which will increase its overall production capacity at some point next year.

While BioNTech’s existing facilities in Mainz produced the first batch of vaccines for clinical trials, most of the manufacturing will be done by Pfizer, which will produce and ship the vaccine worldwide. Doses for the EU, which is on the verge of signing a deal for 300m doses, will be manufactured primarily at Pfizer’s factory in Belgium.

How will it be distributed? At present, BioNTech’s vaccine must be stored at approximately minus 75 degrees Celsius while being transported, making it difficult to deliver to developing countries without robust logistics infrastructure.

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by Anonymousreply 207November 10, 2020 8:51 PM

The vast majority of doses available in the next year, however, have already been bought by the US, EU and Japan, where shipping hypercold products is far easier.

Once it arrives in clinics, the vaccine — which can be kept at approximately minus 75C for up to six months — can survive in a normal fridge for up to 5 days.

Pfizer has said it will use a network of existing distribution centres in the US and elsewhere to make sure the product reaches hospitals and surgeries still frozen. The vaccine will be sent directly to these locations in so-called “thermal shippers” that can carry between 200 and 1,000 vials each, and where the temperature will be constantly monitored by GPS, it said.

BioNTech said the freezing transport conditions, however, were just a “matter of caution” and predicted further testing of the vaccine would show that some of those precautions can be relaxed in the future.

“I believe that upcoming stability data will support storage conditions that are not much different from any other vaccine,” said Mr Sahin.

How much will it cost? Unlike some of its rivals, BioNTech and Pfizer have not promised to supply the vaccine on a not-for-profit basis. In the US, the companies sold at least 100m doses to the government at $19.50 each, but the amounts paid by other countries — including the UK — have not been disclosed.

Ryan Richardson, chief strategy officer for BioNTech, told the FT Global Pharmaceutical and Biotechnology Conference on Tuesday that the company would adopt “differential pricing” in different regions and price the vaccine “well below typical market rates reflecting the situation that we're in and with the goal to ensure broad-based access around the world”.

Mr Richardson added that the company had invested more than $1bn to develop its innovative mRNA technology platform. “What we’ve tried to do in this case is pursue a balanced approach that recognises that innovation requires capital and investment.”

by Anonymousreply 208November 10, 2020 8:53 PM

That's why they're culling the mink, r197.

by Anonymousreply 209November 10, 2020 8:54 PM

I know R209 but it’s not in time now, is it? You are right but it’s already out there. I believe 180k Danes are in strict lockdown now because of it. Let’s hope it’ll work.

by Anonymousreply 210November 10, 2020 9:07 PM

Thank you, R166. From R164

by Anonymousreply 211November 10, 2020 10:34 PM

[quote] 690,000 died last year, which is significant lower than in the last but is not inconsequential. You sound like Trump, [R185].

In third world shitholes.

by Anonymousreply 212November 10, 2020 11:39 PM

[quote] There will be no real way to know the full safety profile until at least 2 years out. So, if stock starts getting dumped after 18 months, that would be the tip off that around year 3 they’ll finally announce “Oh and it causes progressive blindness” or “chronic pain” or something. And they’ll be off the hook because it was such a great public service to even invent it.

This is not dragging on for 3 years, for god’s sake

by Anonymousreply 213November 11, 2020 12:51 AM

My pleasure R164 and good to see you oldlez.

by Anonymousreply 214November 11, 2020 1:28 AM

If it needs to be kept that cold, couldn't they just store it in Melania's poosey?

by Anonymousreply 215November 11, 2020 1:35 AM

But wouldn't it grow mushrooms in it from Old Yeller, R215?!

by Anonymousreply 216November 11, 2020 2:22 AM

I bet it ends up being a failure.

by Anonymousreply 217November 11, 2020 2:22 AM

University of Queensland just announced that its vaccine is showing an antibody response equivalent to that in people who have had the virus. It is still in testing like Pfizer's, but CSL is already manufacturing millions of doses in Melbourne.

by Anonymousreply 218November 13, 2020 6:34 AM

I'm not taking it.

by Anonymousreply 219November 13, 2020 6:43 AM

Hmm, die of COVID, or get The Walking Dead created viral "cure"?

by Anonymousreply 220November 13, 2020 6:50 AM

R208, it is going to cost around ÂŁ29 in the U.K. compared to about ÂŁ3 for the AstraZeneca vaccine which is only a few weeks from being ready apparently so because of storage logistic issues with the Pfizer vaccine it is likely that we will be offered the cheaper option in the U.K. although 10 million (5 million vaccines) have been ordered from Pfizer so some people are likely to get it. 40 million of the AstraZeneca one have been ordered so far.

by Anonymousreply 221November 13, 2020 7:22 AM

People who’ve had Covid also get reinfected. I read that a small group of people with very vulnerable health will get antibodies injected. The Dutch blood bank is working on that but they already said the antibody shots have to be repeated monthly. So I personally don’t think the new vaccines will protect people very long.

by Anonymousreply 222November 13, 2020 9:14 AM

Well, R222, if you personally don't think so I guess they should just stop all vaccine development now. Well, that was a nice pipedream but R222 says it's not going to work.

Antibodies from other people die because you aren't replenishing them yourself. Vaccines make your own immune system create its own antibodies. You then get T-cells. They remember the invader after it has gone and after the antibodies, having done their job, disappear over time. When the invader shows up again, the T-cells send out the alarm and the antibody production begins again.

by Anonymousreply 223November 13, 2020 9:38 AM

Even Pfizer says their new vaccine only gives temporary immunity. We have to be patient for a decent vaccine to be developed. It’s not rocket science R223.

by Anonymousreply 224November 13, 2020 10:05 AM

R224, you don't understand immunology OR rocket science. Just stop.

by Anonymousreply 225November 13, 2020 10:20 AM

R221, Bojo's government made a really bad deal if the BioNTech/Pfizer vaccine is going to cost ÂŁ29. The US has agreed to a lower price and the EU an even lower price.

There are still a lot of question marks about the Oxford vaccine and ÂŁ3 sounds way too cheap. It's just part of the Oxford efforts at marketing themselves. I think Moderna will be the next to announce, as they use the same mRNA technology as Pfizer.

by Anonymousreply 226November 13, 2020 10:42 AM

Lots of vaccines need boosters, r224 and new flu vaccines need to be developed each year.

by Anonymousreply 227November 13, 2020 10:43 AM

R221, I believe the UK has ordered 40 million doses of the Pfizer/BioNTech vaccine and 100 million doses of the as yet not ready AstraZeneca/Oxford vaccine.

by Anonymousreply 228November 13, 2020 10:46 AM

Oh, and the EU managed to get an order of 400 million doses of the AstraZeneca vaccine for about ÂŁ2 a dose. Let's see what happens with that one, though.

by Anonymousreply 229November 13, 2020 10:48 AM

'Take' vs 'get'. Perhaps it's a regional thing, like 'soda' vs 'pop'. I've always said 'I'm going to get the shot' or 'I got the shot', but now I hear 'take the shot' so much in the news. I thought that was a British expression, but apparently a lot of Americans say it too.

by Anonymousreply 230November 13, 2020 10:49 AM

R224 I think I’ll rely on experts rather than your feelings. Thanks.

by Anonymousreply 231November 13, 2020 11:05 AM

R226, I assume those prices are for the full vaccine of two shots each which would be half the price for each single dose.

by Anonymousreply 232November 13, 2020 1:42 PM

Side effects include hangover and face pain. Sounds great!

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by Anonymousreply 233November 14, 2020 6:20 AM

Uh, no thanks. I hate hangovers.

by Anonymousreply 234November 14, 2020 7:17 AM

[post redacted because linking to dailymail.co.uk clearly indicates that the poster is either a troll or an idiot (probably both, honestly.) Our advice is that you just ignore this poster but whatever you do, don't click on any link to this putrid rag.]

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by Anonymousreply 235November 14, 2020 9:44 AM

Once you get the vaccine, how long does it take the body to have 90% immunity from Covid? Is it immediate? And do you still need to wear a mask everywhere? How will we know who has had the vaccine and who hasn't once life starts to get back to normal? People will stop wearing masks and distancing at some point, but not all of those people will have been vaccinated.

by Anonymousreply 236November 14, 2020 10:45 AM

R236, from what I've read about the Pfizer vaccine, the 90% number came from one week after the second dose. Since getting infected and developing Covid takes at least a couple of days from exposure, I'd say a lot of that 90% protection was from the first dose which was 28 days before the second dose. The flu vaccine takes about two weeks to reach it's full level of protection.

That's all I can discern from what is currently publicly available. Make of it what you will.

by Anonymousreply 237November 14, 2020 10:54 AM

[quote] How will we know who has had the vaccine and who hasn't once life starts to get back to normal? People will stop wearing masks and distancing at some point, but not all of those people will have been vaccinated.

Admittedly I could be completely wrong here, but here’s my understanding:

If you’re vaccinated you (theoretically) shouldn’t get infected by someone else. So as long as I’m vaccinated I don’t care if you are or not because you can’t make me sick, you can only get sick yourself.

Putting it another way, if you’ve been vaccinated against, say rubella, you shouldn’t get it, so if we pass in the street, it shouldn’t matter that I have it to you.

Disclaimer: I’m speaking theoretically, not actually since the efficacy hasn’t been proven yet.

by Anonymousreply 238November 14, 2020 3:09 PM

A lot of people here don't seem to understand that the vaccine has a 90% efficacy rate, not that it is 90% effective, which isn't the same thing. The press reports have been very misleading about this.

In other words, if you receive the vaccine, you don't become 90% immune. Efficacy rate in this context means that if 100 people are vaccinated, 90 of them will receive immunity.

From Newsweek:

[quote]Of the 43,538 participants, 94 displayed symptoms of coronavirus indicating that the vaccine's efficacy rate is 90 percent, which represents the percentage of participants who received the vaccine and did not display symptoms.

The Newsweek article is linked below. Google "what does 90% effective mean pfizer vaccine" for more.

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by Anonymousreply 239November 14, 2020 7:43 PM

So that means 10% of people who get the vaccine will have 0 protection. How will we know if we’re part of the 10%. I don’t want to be going out all confident and maskless when in reality I have 0 protection.

by Anonymousreply 240November 14, 2020 8:20 PM

Its called herd immunity r240. If 90% of a population is immune you aren't going to have a virus spreading in a population.

by Anonymousreply 241November 14, 2020 8:25 PM

Plus, that 10% probably doesn't have zero immunity. They will, most likely, get a milder case if they do happen to get infected which will be difficult to do in a population where even 60-70% have immunity. (Accounting for the number of people who will refuse to get the vaccine.)

by Anonymousreply 242November 15, 2020 12:34 AM

But what happens when two 10%s get together.

by Anonymousreply 243November 15, 2020 12:40 AM

R243, most likely they won't have it because almost everyone around them will have immunity. That's what herd immunity is. There are portions of the the population now that can't get certain vaccines because of allergies, age, etc.. They are protected by the rest of us. There is a threshold, though. That's why there are starting to be outbreaks of measles and whooping cough again. Because the moronic anti-vaxxers are becoming numerous enough to affect herd immunity levels in certain communities.

by Anonymousreply 244November 15, 2020 12:47 AM

What happens if the 10% mutates into 8% death and 2% severe symptoms that make you wish you were dead? What about that??

I’m not getting this failure of a “vaccine.” Nope.

by Anonymousreply 245November 15, 2020 12:49 AM

I don't think r245 understand how vaccines work.

by Anonymousreply 246November 15, 2020 11:11 AM

I don't think R246 understand [sic] how Datalounge works.

by Anonymousreply 247November 15, 2020 11:29 AM

How does Datalounge work, r247? People spout nonsense about vaccines and make a big deal about a typo?

by Anonymousreply 248November 15, 2020 12:16 PM

Sometimes the signifier for sarcasm can be found in the signature line.

Also, yes about making a big deal about typos.

by Anonymousreply 249November 15, 2020 12:37 PM

R243 There would only be a 1 in 100 chance of two "10%" people getting together, so the odds are good.

by Anonymousreply 250November 15, 2020 1:31 PM

But what if they’re both at the bathhouse?!!

by Anonymousreply 251November 15, 2020 6:38 PM

It should be noted (but of course ignored because it destroys the narrative of every bigoted asshole) that BioNtech is not "German" in the traditional sense. It was founded by a Muslim immigrant scientist in Germany. I guess people only like to hear shit about them when it suits their bigotry. I hope they tell Donny and every bigot refuses to take it.

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by Anonymousreply 252November 15, 2020 6:55 PM

So are the 40,000 people in the trial now running around without a mask and carrying on a normal to see if they still catch it or not?

by Anonymousreply 253November 15, 2020 6:56 PM

Moderna says their vaccine is 94,5% effective.

by Anonymousreply 254November 16, 2020 4:21 PM

[r254] And Moderna's vaccine doesn't have to be stored at extremely cold temperatures

by Anonymousreply 255November 16, 2020 4:24 PM

R253, the trial participants still don't know if they got the vaccine or the placebo (50% chance of each).

by Anonymousreply 256November 16, 2020 4:28 PM

Are the participants in the studies equally comprised of men and women? That has a huge bearing of the safety profile.

by Anonymousreply 257November 16, 2020 4:31 PM

R256 a vaccine that’s 40% effective is like the flu vaccine. I suppose that wouldn’t be an unlikely outcome for the new vaccine(s) either.

by Anonymousreply 258November 16, 2020 4:55 PM

so Pfizer's vaccine is 90% effective and has to be stored at -94°.

Moderna's vaccine is 94.7 effective and can be just refrigerated.

So is the next one going to be 100% and doesn't have to be refrigerated at all?

this all seems way too good to be true. Trump has really made his mark because who can trust any of them?

by Anonymousreply 259November 16, 2020 4:59 PM

It’s good for the pharmaceutical industry too. Is it a coincidence Pfizer’s CEO sold stocks for 5.6 million a few days ago right after the announcement?

by Anonymousreply 260November 16, 2020 5:53 PM

Why is he offloading stocks? Is it a scam vaccine? If it’s real why not wait until the stocks go higher?

by Anonymousreply 261November 16, 2020 6:19 PM

He wasn't "offloading stock". It was a prearranged sale, which was triggered once the share price reached a certain level.

by Anonymousreply 262November 16, 2020 6:21 PM

I thought he dumped it because of the impending news about the better (more effective, less problematic storage) vaccine from Moderna would make Pfizer's less desirable.

by Anonymousreply 263November 16, 2020 7:44 PM

[quote]So are the 40,000 people in the trial now running around without a mask and carrying on a normal to see if they still catch it or not?

I'd assume they are or are not using masks the same way the general population is but the way the trial works is comparing the two groups (vaccine/placebo) infection rates to each other, not the general public.

by Anonymousreply 264November 16, 2020 7:49 PM

Except r263 his shares were automatically sold 7 days before the Moderna announcement.

by Anonymousreply 265November 16, 2020 7:50 PM

moderna's vaccine seen as nearly 95% effective in preventing infection

Offsite Link
by Anonymousreply 266November 16, 2020 7:53 PM

[quote] this all seems way too good to be true.

I understand what you mean, but I saw something on one of the news networks that China theoretically had a vaccine in December but, the only way I can describe it is to say it wasn’t ready. Whether that means tested, didn’t work on this particular coronavirus or what, I don’t know.

And there's been work on a coronavirus vaccine for years prior, so it’s not that unusual.

by Anonymousreply 267November 16, 2020 8:04 PM

We only have Miz Moderna's say-so.

I'm curbing my enthusiasm for the time being.

by Anonymousreply 268November 16, 2020 8:05 PM

R267 yes the SARS viruses we already knew but not COVID-19

by Anonymousreply 269November 16, 2020 8:08 PM

I'm not. I'm having great hope for a semi normal fall 2021.

by Anonymousreply 270November 16, 2020 8:08 PM

[quote] I understand what you mean, but I saw something on one of the news networks that China theoretically had a vaccine in December but, the only way I can describe it is to say it wasn’t ready.

December isn’t even here yet so theoretically it could be ready when they announce it next month.

by Anonymousreply 271November 16, 2020 8:09 PM

December of 2019, obviously.

by Anonymousreply 272November 16, 2020 8:11 PM

I’m not getting this experimental vaccine. I’ll let you all be the guinea pigs. All I know is nobody better fuck with the handful of anti-retrovirals I take on a daily basis so I can accept daily anonymous loads.

by Anonymousreply 273November 16, 2020 8:12 PM

Yes, r269, that was the point. They had somewhat of a head start, so to speak.

by Anonymousreply 274November 16, 2020 8:13 PM

[quote] I’ll let you all be the guinea pigs.

Oh, hey, oh, what’s wid the language, hah? Whatsa matta for you? You ain’t gotta bring ethnicity into this, capisce?

by Anonymousreply 275November 16, 2020 8:15 PM

I've had the virus and am tempted to wait this out. It should be completely gone by the end of 2021/22. It will disappear like the Spanish flu did but not until after it takes many lives. Trump had it right but didn't understand the timeline and thought it would be gone before it did any harm.

by Anonymousreply 276November 16, 2020 8:25 PM

Furthermore r263, Moderna's success actually bolsters the Pfizer/BioNTech vaccine because it's further proof that the mRNA technology is effective and seemingly better than the more traditional vaccines being developed by Oxford, etc. Since BioNTech and Pfizer are doing lots of other work with mRNA, the strengthening credibility of mRNA can only be good for them.

by Anonymousreply 277November 16, 2020 8:25 PM

Trump had what right, r277?

by Anonymousreply 278November 16, 2020 8:26 PM

r278 that it would just disappear

by Anonymousreply 279November 16, 2020 8:28 PM

R279 true it happens with every pandemic.

by Anonymousreply 280November 16, 2020 8:39 PM

It's sad because the US has already paid Pfizer over $1 billion to get millions of doses of its vaccine. The US will spend billions more transporting and storing this vaccine at subzero temperatures--all the while, the Moderna vaccine only requires regular refrigeration.

by Anonymousreply 281November 16, 2020 9:24 PM

[quote] It will disappear like the Spanish flu did but not until after it takes many lives.

The Spanish flu didn't just disappear. There were strong measures in place at the time, especially with regards to mask wearing. Interesting, all the subsequent deadly flu pandemics (1957 and others after that), all were genetics variations that started with that original Spanish flu.

by Anonymousreply 282November 16, 2020 9:26 PM

[quote] true it happens with every pandemic.

Pandemics don't just disappear on their own--we actually take measures against them. We either eradicate the source or build up herd immunity (most strongly through vaccination). In every case, we have to be very active in order to get rid of it.

by Anonymousreply 283November 16, 2020 9:29 PM

R281, no single company will be able to produce enough vaccine for all so we need more than one and the supposed logistical difficulties of the Pfizer vaccine are way over-exaggerated.

by Anonymousreply 284November 16, 2020 9:33 PM

[quote] and the supposed logistical difficulties of the Pfizer vaccine are way over-exaggerated.

True. I just heard that it’s shipped in its own container that keeps it cold with dry ice. If necessary, you replace the dry ice.

by Anonymousreply 285November 16, 2020 9:54 PM

I only have 50 shares of Pfizer stock but I still can’t understand why it hasn’t gone up even when the announcement was made - what’s up with this stock??

by Anonymousreply 286November 16, 2020 9:59 PM

[quote] Pfizer stock but I still can’t understand why it hasn’t gone up

Try their other pill, that may help.

by Anonymousreply 287November 16, 2020 10:08 PM

[quote] My epidemiologist friends say this is interesting, but will need to see the results themselves, and that could take months.

Now that Pfizer’s has been making the rounds to frontline healthcare workers and Moderna’s is about to be unleashed as well, what are your epidemiologist friends saying? Are they still finding it “interesting”?

by Anonymousreply 288December 17, 2020 10:37 PM
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